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• W2011181574 abstract "A number of dioxolane, dioxane, and dioxepine quinazoline derivatives have been synthetized and evaluated as EGFR inhibitors. Their cytotoxic activity has been tested against two cell lines overexpressing and not expressing EGFR. Most derivatives were able to counteract EGF-induced EGFR phosphorylation, and their potency was comparable to the reference compound PD153035. The size of the fused dioxygenated ring was crucial for the biological activity, the dioxane derivatives being the most promising class of this series." @default.
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• W2011181574 date "2010-01-22" @default.
• W2011181574 modified "2023-10-16" @default.
• W2011181574 title "Exploring Epidermal Growth Factor Receptor (EGFR) Inhibitor Features: The Role of Fused Dioxygenated Rings on the Quinazoline Scaffold" @default.
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• W2011181574 doi "https://doi.org/10.1021/jm901338g" @default.
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