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- W2011181815 abstract "Experimental autoimmune myasthenia gravis (EAMG) is caused by autoantibodies against the nicotinic acetylcholine receptor (AChR) at the neuromuscular postsynaptic membrane and represents an animal model of myasthenia gravis in human. Recent studies highlighted the roles of TH1 cytokines (IFN-γ, IL-12), rather than TH2 cytokines (IL-4), in the pathogenesis of EAMG by using homozygous (−/−) knockout mice with an EAMG-susceptible genetic background. To further evaluate a role for IFN-γ, we injected recombinant rat IFN-γ (rrIFN-γ) at the time of immunization with AChR in complete Freund's adjuvant to EAMG-susceptible Lewis rats and EAMG-resistant Wistar Furth (WF) rats. RrIFN-γ enhanced Lewis rat EAMG. The exacerbated muscular weakness was associated with higher levels of anti-AChR IgG and enhanced TNF-α responses. Anti-AChR IgG antibody levels were augmented to a similar extent as in Lewis rats, however, the identical immunization and IFN-γ injection induced only mild and transient EAMG in WF rats due to the default TH3 phenotype development and inherent low TH1 responses. We conclude that IFN-γ plays a major role in the pathogenesis of EAMG in the Lewis rat, but fails to break disease resistance in the WF rat." @default.
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- W2011181815 date "2000-05-01" @default.
- W2011181815 modified "2023-10-16" @default.
- W2011181815 title "Role for Interferon-γ in Rat Strains with Different Susceptibility to Experimental Autoimmune Myasthenia Gravis" @default.
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- W2011181815 doi "https://doi.org/10.1006/clim.2000.4850" @default.
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