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- W2011182785 abstract "A monolithically integrated SOS/FET multi-biosensor has been realized. The multi-biosensor has four ISFETs, and can detect urea, glucose and potassium simultaneously. Four MOSFET pairs constitute source follower circuits, where an individual MOSFET works as a simple quasi-constant current synthesizing circuit, and needs only two constant voltage power supplies. The gate potential of an ISFET can be measured as an ISFET source potential, so differential measurements can easily be realized. By using a gold layer deposited on the sapphire back surface as a pseudo-reference electrode, and substrate concentration, of urea for example, is measured as a differential output between an ISFET modified by urease, for example, and a normal ISFET. Two of the four ISFET surfaces were modified by glucose oxidase and urease, respectively. One of the remaining ISFETs is modified by a liquid membrane that contains valinomycin as a potassium-sensitive ionophore. The last ISFET has an albumin crosslinking membrane on the surface. Minute amounts of enzyme or ionophore were used as sensitive elements. The differential output from the ISFETs shows a good relationship with glucose concentration from 1 to 50 mg/dl and with urea from 1 to 100 mg/dl, and shows a linear relationship with potassium from 10−3 to 2 × 10−2 Eq/l." @default.
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- W2011182785 date "1986-07-01" @default.
- W2011182785 modified "2023-10-14" @default.
- W2011182785 title "An integrated SOS/FET multi-biosensor" @default.
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- W2011182785 doi "https://doi.org/10.1016/0250-6874(86)80069-5" @default.
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