Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011183043> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2011183043 endingPage "78" @default.
- W2011183043 startingPage "71" @default.
- W2011183043 abstract "Oral tolerance is being promoted as a therapy for autoimmune diseases and therefore will need to be functional in a primed immune system. In previous studies, we found that although primed mice could be tolerized by feeding ovalbumin (OVA), the degree of the tolerance and its effects on individual components of the systemic immune response were more limited than that found in naive animals. Here we increased the dose and frequency of antigen feeding in an attempt to extend the effects of oral tolerance in primed mice and to understand why its effects are limited under these conditions. Increasing the amounts of OVA fed, up to a single dose of 400 mg, or using multiple feeds of 5 x 5 or 5 x 25 mg OVA, did not radically alter the extent of tolerance, with DTH responses, antigen-specific proliferation, and IL5 and IFN-gamma production still being tolerized, but antibody responses remaining generally resistant. The deficient tolerance in primed mice could not be overcome by waiting for maximum clonal expansion to wane and was not influenced by persistent release of antigen from a depot adjuvant. We conclude that the resistance of primed mice to oral tolerance may be due to the fact that antigen-experienced T cells may be inherently resistant to induction of tolerance, or that the microenvironment of the primed immune system inhibits the delivery of tolerogenic signals to antigen-specific T cells." @default.
- W2011183043 created "2016-06-24" @default.
- W2011183043 creator A5008793894 @default.
- W2011183043 creator A5051046892 @default.
- W2011183043 creator A5068519558 @default.
- W2011183043 date "2000-06-01" @default.
- W2011183043 modified "2023-09-29" @default.
- W2011183043 title "Induction of Oral Tolerance in the Primed Immune System: Influence of Antigen Persistence and Adjuvant Form" @default.
- W2011183043 cites W1485596855 @default.
- W2011183043 cites W1533770469 @default.
- W2011183043 cites W1548445641 @default.
- W2011183043 cites W1579431146 @default.
- W2011183043 cites W1600526298 @default.
- W2011183043 cites W1606317751 @default.
- W2011183043 cites W1698089433 @default.
- W2011183043 cites W1905494569 @default.
- W2011183043 cites W1932940961 @default.
- W2011183043 cites W1935216754 @default.
- W2011183043 cites W1960767717 @default.
- W2011183043 cites W1968261783 @default.
- W2011183043 cites W1968274103 @default.
- W2011183043 cites W1987049857 @default.
- W2011183043 cites W1988317772 @default.
- W2011183043 cites W1992949591 @default.
- W2011183043 cites W1993933931 @default.
- W2011183043 cites W2016478391 @default.
- W2011183043 cites W2018590888 @default.
- W2011183043 cites W2019965911 @default.
- W2011183043 cites W2020317622 @default.
- W2011183043 cites W2021037397 @default.
- W2011183043 cites W2025445086 @default.
- W2011183043 cites W2034249407 @default.
- W2011183043 cites W2038358976 @default.
- W2011183043 cites W2044163622 @default.
- W2011183043 cites W2065973297 @default.
- W2011183043 cites W2068331312 @default.
- W2011183043 cites W2075376701 @default.
- W2011183043 cites W2094525699 @default.
- W2011183043 cites W2095329224 @default.
- W2011183043 cites W2101824917 @default.
- W2011183043 cites W2149764521 @default.
- W2011183043 cites W2161517279 @default.
- W2011183043 cites W2161817457 @default.
- W2011183043 cites W2163682172 @default.
- W2011183043 cites W2171403211 @default.
- W2011183043 doi "https://doi.org/10.1006/cimm.2000.1665" @default.
- W2011183043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10896766" @default.
- W2011183043 hasPublicationYear "2000" @default.
- W2011183043 type Work @default.
- W2011183043 sameAs 2011183043 @default.
- W2011183043 citedByCount "41" @default.
- W2011183043 countsByYear W20111830432012 @default.
- W2011183043 countsByYear W20111830432013 @default.
- W2011183043 countsByYear W20111830432015 @default.
- W2011183043 countsByYear W20111830432018 @default.
- W2011183043 countsByYear W20111830432022 @default.
- W2011183043 crossrefType "journal-article" @default.
- W2011183043 hasAuthorship W2011183043A5008793894 @default.
- W2011183043 hasAuthorship W2011183043A5051046892 @default.
- W2011183043 hasAuthorship W2011183043A5068519558 @default.
- W2011183043 hasConcept C147483822 @default.
- W2011183043 hasConcept C203014093 @default.
- W2011183043 hasConcept C2776946954 @default.
- W2011183043 hasConcept C2777702733 @default.
- W2011183043 hasConcept C2777863537 @default.
- W2011183043 hasConcept C2910153128 @default.
- W2011183043 hasConcept C86803240 @default.
- W2011183043 hasConcept C8891405 @default.
- W2011183043 hasConceptScore W2011183043C147483822 @default.
- W2011183043 hasConceptScore W2011183043C203014093 @default.
- W2011183043 hasConceptScore W2011183043C2776946954 @default.
- W2011183043 hasConceptScore W2011183043C2777702733 @default.
- W2011183043 hasConceptScore W2011183043C2777863537 @default.
- W2011183043 hasConceptScore W2011183043C2910153128 @default.
- W2011183043 hasConceptScore W2011183043C86803240 @default.
- W2011183043 hasConceptScore W2011183043C8891405 @default.
- W2011183043 hasIssue "2" @default.
- W2011183043 hasLocation W20111830431 @default.
- W2011183043 hasLocation W20111830432 @default.
- W2011183043 hasOpenAccess W2011183043 @default.
- W2011183043 hasPrimaryLocation W20111830431 @default.
- W2011183043 hasRelatedWork W1976579146 @default.
- W2011183043 hasRelatedWork W1983325185 @default.
- W2011183043 hasRelatedWork W2011183043 @default.
- W2011183043 hasRelatedWork W2017826569 @default.
- W2011183043 hasRelatedWork W2033998433 @default.
- W2011183043 hasRelatedWork W2034707118 @default.
- W2011183043 hasRelatedWork W2736540239 @default.
- W2011183043 hasRelatedWork W3109192410 @default.
- W2011183043 hasRelatedWork W3177238328 @default.
- W2011183043 hasRelatedWork W3118555403 @default.
- W2011183043 hasVolume "202" @default.
- W2011183043 isParatext "false" @default.
- W2011183043 isRetracted "false" @default.
- W2011183043 magId "2011183043" @default.
- W2011183043 workType "article" @default.