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• W201118480 abstract "Gene delivery to the adult rodent brain can be achieved using recombinant virus vectors derived from herpes simplex virus type 1 (HSV-1). This double stranded DNA virus has a large genome (150 kb) which may carry up to 50 kb of foreign DNA at replaceable sites. This virus has a number of advantages for delivery of genes to neurons. It can be taken up by nerve terminals and transported by rapid retrograde transport to the cell nucleus; it can be passed transsynaptically between neurons; and it can enter latency in many types of neurons and possibly other cell types. In latency, the virus exists in a stable and essentially benign form in the nucleus, with active transcription predominantly from one viral promoter. Our group and others have generated vectors which are replication-compromised or replication-defective and have diminished pathogenicity to animals. These vectors can confer both short- and long-term expression of foreign genes on neurons in the peripheral and central nervous systems. Examples will be given here for gene delivery to the adult rat nervous system using vectors which lack viral thymidine kinase activity and cannot replicate in neurons, focusing on the use of two non-herpes virus promoters — the Moloney murine leukemia virus (MoMLV) long terminal repeat (LTR) promoter and the rat neuronal specific enolase promoter — to confer expression of the E. coli lacZ gene on neural cells in the brain. Herpes vectors can potentially be used to change the physiology of specific sets of endogenous neurons following stereotactic inoculation into the rat brain. This gene delivery scheme might prove useful in therapeutic paradigms where subsets of neurons need to be reprogrammed to augment their survival or function." @default.
• W201118480 created "2016-06-24" @default.
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• W201118480 date "1992-01-01" @default.
• W201118480 modified "2023-10-03" @default.
• W201118480 title "Gene Transfer into the Nervous System using Recombinant Herpes Virus Vectors" @default.
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• W201118480 doi "https://doi.org/10.1007/978-3-642-84842-1_10" @default.
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