FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011185588> ?p ?o ?g. }

• W2011185588 endingPage "199" @default.
• W2011185588 startingPage "192" @default.
• W2011185588 abstract "Interleukin (IL)-1beta and tumor necrosis factor (TNF)-alpha released from alveolar macrophages (AM) in pulmonary tuberculosis (TB) are important in host defense against mycobacterial infection. Nitric oxide (NO) production is enhanced in AM of TB patients. We examined whether NO was implicated in (IL)-1beta and TNF-alpha synthesis by AM of TB patients. Purified AM were retrieved by bronchoalveolar lavage from 11 TB patients and 10 normal subjects, and were cultured with or without the NO inhibitor N(G)-monomethyl-L-arginine (L-NMMA). The release of IL-1beta and TNF-alpha, and expression of their messenger RNAs (mRNAs), were determined by enzyme-linked immunosorbent assay and Northern blot analysis. The release of IL-1beta and TNF-alpha was greater from AM of TB patients than from AM of normal subjects. L-NMMA inhibited nitrite, IL-1beta, and TNF-alpha production in TB patients. The mRNA expression for IL-1beta and TNF-alpha was upregulated in TB patients and was depressed by L-NMMA. Immunocytochemistry done with a monoclonal antibody against the p65 subunit of nuclear factor (NF)-kappaB showed that NF-kappaB was highly expressed and translocated to the nuclei of AM from TB patients, and was inhibited by L-NMMA. Inhibition of NF-kappaB by pyrrolidine dithiocarbamate attenuated IL-1beta and TNF-alpha synthesis. In conclusion, enhanced NO generation by AM of TB patients plays an autoregulatory role in amplifying the synthesis of proinflammatory cytokines, probably through NF-kappaB activation." @default.
• W2011185588 created "2016-06-24" @default.
• W2011185588 creator A5004205888 @default.
• W2011185588 creator A5015142199 @default.
• W2011185588 creator A5020342771 @default.
• W2011185588 creator A5040621580 @default.
• W2011185588 creator A5049201518 @default.
• W2011185588 creator A5067173088 @default.
• W2011185588 creator A5075275067 @default.
• W2011185588 date "2000-01-01" @default.
• W2011185588 modified "2023-09-27" @default.
• W2011185588 title "Nitric Oxide Modulates Interleukin-1 β and Tumor Necrosis Factor- α Synthesis by Alveolar Macrophages in Pulmonary Tuberculosis" @default.
• W2011185588 cites W1891003501 @default.
• W2011185588 cites W1909744463 @default.
• W2011185588 cites W1941717575 @default.
• W2011185588 cites W1967255828 @default.
• W2011185588 cites W1974913456 @default.
• W2011185588 cites W1987706044 @default.
• W2011185588 cites W1998380451 @default.
• W2011185588 cites W2005069877 @default.
• W2011185588 cites W2017487826 @default.
• W2011185588 cites W2017922713 @default.
• W2011185588 cites W2051444452 @default.
• W2011185588 cites W2060799103 @default.
• W2011185588 cites W2061256473 @default.
• W2011185588 cites W2072598801 @default.
• W2011185588 cites W2075946395 @default.
• W2011185588 cites W2087587775 @default.
• W2011185588 cites W2089199666 @default.
• W2011185588 cites W2100219870 @default.
• W2011185588 cites W2109654316 @default.
• W2011185588 cites W2114220827 @default.
• W2011185588 cites W2128494605 @default.
• W2011185588 cites W2142006275 @default.
• W2011185588 cites W2143590308 @default.
• W2011185588 cites W2160823100 @default.
• W2011185588 cites W2164450432 @default.
• W2011185588 cites W2180743237 @default.
• W2011185588 cites W2182302387 @default.
• W2011185588 cites W2244825722 @default.
• W2011185588 cites W2289765096 @default.
• W2011185588 cites W2344310512 @default.
• W2011185588 cites W4294216491 @default.
• W2011185588 doi "https://doi.org/10.1164/ajrccm.161.1.9902113" @default.
• W2011185588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10619820" @default.
• W2011185588 hasPublicationYear "2000" @default.
• W2011185588 type Work @default.
• W2011185588 sameAs 2011185588 @default.
• W2011185588 citedByCount "58" @default.
• W2011185588 countsByYear W20111855882012 @default.
• W2011185588 countsByYear W20111855882013 @default.
• W2011185588 countsByYear W20111855882014 @default.
• W2011185588 countsByYear W20111855882015 @default.
• W2011185588 countsByYear W20111855882016 @default.
• W2011185588 countsByYear W20111855882017 @default.
• W2011185588 countsByYear W20111855882018 @default.
• W2011185588 countsByYear W20111855882020 @default.
• W2011185588 countsByYear W20111855882021 @default.
• W2011185588 countsByYear W20111855882022 @default.
• W2011185588 crossrefType "journal-article" @default.
• W2011185588 hasAuthorship W2011185588A5004205888 @default.
• W2011185588 hasAuthorship W2011185588A5015142199 @default.
• W2011185588 hasAuthorship W2011185588A5020342771 @default.
• W2011185588 hasAuthorship W2011185588A5040621580 @default.
• W2011185588 hasAuthorship W2011185588A5049201518 @default.
• W2011185588 hasAuthorship W2011185588A5067173088 @default.
• W2011185588 hasAuthorship W2011185588A5075275067 @default.
• W2011185588 hasConcept C126322002 @default.
• W2011185588 hasConcept C142724271 @default.
• W2011185588 hasConcept C153911025 @default.
• W2011185588 hasConcept C164027704 @default.
• W2011185588 hasConcept C17991360 @default.
• W2011185588 hasConcept C203014093 @default.
• W2011185588 hasConcept C2776178081 @default.
• W2011185588 hasConcept C2776914184 @default.
• W2011185588 hasConcept C2777622882 @default.
• W2011185588 hasConcept C2777714996 @default.
• W2011185588 hasConcept C2777730290 @default.
• W2011185588 hasConcept C2777961210 @default.
• W2011185588 hasConcept C2778543330 @default.
• W2011185588 hasConcept C2778690821 @default.
• W2011185588 hasConcept C2780983412 @default.
• W2011185588 hasConcept C2908937200 @default.
• W2011185588 hasConcept C519581460 @default.
• W2011185588 hasConcept C71924100 @default.
• W2011185588 hasConcept C74172505 @default.
• W2011185588 hasConcept C86803240 @default.
• W2011185588 hasConceptScore W2011185588C126322002 @default.
• W2011185588 hasConceptScore W2011185588C142724271 @default.
• W2011185588 hasConceptScore W2011185588C153911025 @default.
• W2011185588 hasConceptScore W2011185588C164027704 @default.
• W2011185588 hasConceptScore W2011185588C17991360 @default.
• W2011185588 hasConceptScore W2011185588C203014093 @default.
• W2011185588 hasConceptScore W2011185588C2776178081 @default.
• W2011185588 hasConceptScore W2011185588C2776914184 @default.
• W2011185588 hasConceptScore W2011185588C2777622882 @default.
• W2011185588 hasConceptScore W2011185588C2777714996 @default.
• W2011185588 hasConceptScore W2011185588C2777730290 @default.

• next