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• W2011188088 abstract "The adolescent brain is particularly vulnerable to the effects of alcohol, with intoxications at this developmental age often producing long-lasting effects. The present study addresses the effects of a single acute ethanol exposure on growth-associated protein-43 (GAP-43) and brain-derived neurotrophic factor (BDNF) gene expression in neurons in the cerebellum and hippocampus of adolescent rats. Male postnatal day 23 (P23) Sprague–Dawley rats were exposed to ethanol vapors for 2 h and after a recovery period of 2 h, the cerebellum and hippocampus were harvested and samples were taken for blood alcohol concentration (BAC) determinations. We found that this exposure resulted in a mean BAC of 174 mg/dL, which resembles levels in human adolescents after binge drinking. Analyses of total RNA and protein by quantitative reverse transcription PCR and western blotting, respectively, revealed that this single ethanol exposure significantly decreased the levels of GAP-43 mRNA and protein in the cerebellum but increased the levels of mRNA and protein in the hippocampus. BDNF mRNA and protein levels were also increased in the hippocampus but not in the cerebellum of these animals. In situ hybridizations revealed that GAP-43 and BDNF mRNA levels were primarily increased by alcohol exposure in hippocampal dentate granule cells and CA3 neurons. Overall, the reported alterations in the expression of the plasticity-associated genes GAP-43 and BDNF in juvenile rats are consistent with the known deleterious effects of binge drinking on motor coordination and cognitive function." @default.
• W2011188088 created "2016-06-24" @default.
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• W2011188088 date "2011-08-01" @default.
• W2011188088 modified "2023-10-14" @default.
• W2011188088 title "Opposite effects of acute ethanol exposure on GAP-43 and BDNF expression in the hippocampus versus the cerebellum of juvenile rats" @default.
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• W2011188088 doi "https://doi.org/10.1016/j.alcohol.2010.12.004" @default.
• W2011188088 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3119774" @default.
• W2011188088 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21367572" @default.
• W2011188088 hasPublicationYear "2011" @default.
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