Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011189236> ?p ?o ?g. }
- W2011189236 endingPage "67" @default.
- W2011189236 startingPage "67" @default.
- W2011189236 abstract "Type 1 diabetes (T1D) is an autoimmune disorder caused by inflammatory destruction of the pancreatic tissue. The etiopathogenesis and characteristics of the pathologic process of pancreatic destruction are well described. In addition, the putative susceptibility genes for T1D as a monoglandular disease and the relation to polyglandular autoimmune syndrome (PAS) have also been well explored. The incidence of T1D has steadily increased in most parts of the world, especially in industrialized nations. T1D is frequently associated with autoimmune endocrine and non-endocrine diseases and patients with T1D are at a higher risk for developing several glandular autoimmune diseases. Familial clustering is observed, which suggests that there is a genetic predisposition. Various hypotheses pertaining to viral- and bacterial-induced pancreatic autoimmunity have been proposed, however a definitive delineation of the autoimmune pathomechanism is still lacking. In patients with PAS, pancreatic and endocrine autoantigens either colocalize on one antigen-presenting cell or are expressed on two/various target cells sharing a common amino acid, which facilitates binding to and activation of T cells. The most prevalent PAS phenotype is the adult type 3 variant or PAS type III, which encompasses T1D and autoimmune thyroid disease. This review discusses the findings of recent studies showing noticeable differences in the genetic background and clinical phenotype of T1D either as an isolated autoimmune endocrinopathy or within the scope of polyglandular autoimmune syndrome." @default.
- W2011189236 created "2016-06-24" @default.
- W2011189236 creator A5012773567 @default.
- W2011189236 creator A5080138937 @default.
- W2011189236 creator A5087797414 @default.
- W2011189236 date "2015-01-01" @default.
- W2011189236 modified "2023-10-05" @default.
- W2011189236 title "Type 1 diabetes and polyglandular autoimmune syndrome: A review" @default.
- W2011189236 cites W122537507 @default.
- W2011189236 cites W136910319 @default.
- W2011189236 cites W1491849748 @default.
- W2011189236 cites W1510924430 @default.
- W2011189236 cites W1519521580 @default.
- W2011189236 cites W1541384425 @default.
- W2011189236 cites W1602704667 @default.
- W2011189236 cites W1648634349 @default.
- W2011189236 cites W166498796 @default.
- W2011189236 cites W182977279 @default.
- W2011189236 cites W1902709718 @default.
- W2011189236 cites W1966095530 @default.
- W2011189236 cites W1968830994 @default.
- W2011189236 cites W1969814939 @default.
- W2011189236 cites W1971781183 @default.
- W2011189236 cites W1973964927 @default.
- W2011189236 cites W1974377151 @default.
- W2011189236 cites W1976205269 @default.
- W2011189236 cites W1977807166 @default.
- W2011189236 cites W1977957847 @default.
- W2011189236 cites W1979075129 @default.
- W2011189236 cites W1981554751 @default.
- W2011189236 cites W1983858481 @default.
- W2011189236 cites W1985881712 @default.
- W2011189236 cites W1985911547 @default.
- W2011189236 cites W1986656063 @default.
- W2011189236 cites W1987114618 @default.
- W2011189236 cites W1987677365 @default.
- W2011189236 cites W1988977978 @default.
- W2011189236 cites W1989137853 @default.
- W2011189236 cites W1990040680 @default.
- W2011189236 cites W1992560150 @default.
- W2011189236 cites W1993249613 @default.
- W2011189236 cites W1993312496 @default.
- W2011189236 cites W1996624137 @default.
- W2011189236 cites W1997112242 @default.
- W2011189236 cites W1997449038 @default.
- W2011189236 cites W1999607466 @default.
- W2011189236 cites W2000498157 @default.
- W2011189236 cites W2000549941 @default.
- W2011189236 cites W2000856655 @default.
- W2011189236 cites W2001199930 @default.
- W2011189236 cites W2001928379 @default.
- W2011189236 cites W2005669636 @default.
- W2011189236 cites W2007595794 @default.
- W2011189236 cites W2008865088 @default.
- W2011189236 cites W2009729495 @default.
- W2011189236 cites W2010328347 @default.
- W2011189236 cites W2011108094 @default.
- W2011189236 cites W2011407843 @default.
- W2011189236 cites W2011450045 @default.
- W2011189236 cites W2013987979 @default.
- W2011189236 cites W2017377709 @default.
- W2011189236 cites W2017421022 @default.
- W2011189236 cites W2017695531 @default.
- W2011189236 cites W2019979646 @default.
- W2011189236 cites W2023259605 @default.
- W2011189236 cites W2024235219 @default.
- W2011189236 cites W2024286178 @default.
- W2011189236 cites W2026835668 @default.
- W2011189236 cites W2027613359 @default.
- W2011189236 cites W2028484154 @default.
- W2011189236 cites W2029840481 @default.
- W2011189236 cites W2030013264 @default.
- W2011189236 cites W2030660601 @default.
- W2011189236 cites W2030761948 @default.
- W2011189236 cites W2031529855 @default.
- W2011189236 cites W2031983540 @default.
- W2011189236 cites W2034877810 @default.
- W2011189236 cites W2035623886 @default.
- W2011189236 cites W2036048098 @default.
- W2011189236 cites W2036511637 @default.
- W2011189236 cites W2037969658 @default.
- W2011189236 cites W2038262329 @default.
- W2011189236 cites W2038621360 @default.
- W2011189236 cites W2043107413 @default.
- W2011189236 cites W2044320967 @default.
- W2011189236 cites W2048360877 @default.
- W2011189236 cites W2048548715 @default.
- W2011189236 cites W2053387251 @default.
- W2011189236 cites W2058957989 @default.
- W2011189236 cites W2059704957 @default.
- W2011189236 cites W2060312395 @default.
- W2011189236 cites W2062573090 @default.
- W2011189236 cites W2064379915 @default.
- W2011189236 cites W2067309350 @default.
- W2011189236 cites W2068738555 @default.
- W2011189236 cites W2068845941 @default.
- W2011189236 cites W2069605085 @default.
- W2011189236 cites W2073688589 @default.