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• W2011191432 endingPage "103" @default.
• W2011191432 startingPage "91" @default.
• W2011191432 abstract "The effects of ACTH and 8-Br-cAMP on growth and replication of a functional mouse adrenal tumor cell line (Y-1) were investigated. ACTH and 8-Br-cAMP both inhibited DNA synthesis and replication when added to randomly growing cell cultures. ACTH addition and serum deprivation each arrested cells in G1; an additional point of arrest in G2 occurred with 8-Br-cAMP. Cells whose growth was arrested in G1 by ACTH had a significantly larger volume and protein and RNA content compared to cells arrested in G1 by serum deprivation. When ACTH or 8-Br-cAMP was added with serum to cells arrested by serum deprivation, the wave of DNA synthesis and cell division seen with serum was abolished. ACTH and 8-Br-cAMP had no effect on the serum-induced increases in protein and RNA content, rates of leucine incorporation into protein and uridine incorporation into RNA, and RNA polymerase I activity observed in cells during the pre-replicative period. Partial inhibition of the serum-induced increase in uridine transport occurred. ACTH and cAMP do not appear to inhibit replication by generalized negative pleiotypic effects but rather to inhibit the initiation of DNA synthesis more specifically. The ACTH-arrested Y-1 cell resembles an in vivo hypertrophied adrenal cortical cell." @default.
• W2011191432 created "2016-06-24" @default.
• W2011191432 creator A5050112368 @default.
• W2011191432 creator A5050209658 @default.
• W2011191432 date "1977-01-01" @default.
• W2011191432 modified "2023-09-27" @default.
• W2011191432 title "Differential effects of ACTH or 8-Br-cAMP on growth and replication in a functional adrenal tumor cell line" @default.
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• W2011191432 doi "https://doi.org/10.1002/jcp.1040900112" @default.
• W2011191432 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/188854" @default.
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