FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011193016> ?p ?o ?g. }

• W2011193016 endingPage "72" @default.
• W2011193016 startingPage "63" @default.
• W2011193016 abstract "The effects of testosterone on androgen metabolizing enzymes were examined in the developing hypothalamus of male and female quail using an in vitro radiometric assay which measures metabolite formation in individual brain samples. Testosterone (T) administered by subcutaneous silastic implants to gonadectomized 4-day-old chicks increased formation of estradiol-17 beta (E2) in both preoptic area + anterior hypothalamus (PA) and posterior hypothalamus + tuberal area (HT) to adult levels. The T-induced increase in E2 formation occurred to the same degree in both sexes. The increase was very small in control non-target areas, neostriatum intermediale + hyperstriatum ventrale (VN), of either sex. Testosterone had no effect on formation of 5 alpha-dihydrotestosterone (5 alpha-DHT), 5 beta-dihydrotestosterone (5 beta-DHT) and 5 beta-androstane 3 alpha, 17 beta-diol (5 beta, 3 alpha-diol) in PA. Kinetic analysis of the rate of E2 production by hypothalamic tissue from castrated chicks (CX-chicks) and castrates treated with T (CX + T-chicks) indicates that the increase in hypothalamic aromatase activity by T corresponds to induction of the enzyme: the Vmax (maximum velocity) was increased by T (CX-chicks, 21; CX + T-chicks, 91 fmol/mg FW/h), whereas the Km was unaffected (CX-chicks, 5.5; CX + T-chicks, 4.7 X 10(-8) M). Testosterone treatment, effective for inducing PA and HT aromatase activity, also activated crowing and caused cloacal gland development; neither of these effects were sexually dimorphic. Our results indicate that: (1) T induces aromatase specifically in the hypothalamus during early post-hatching development, other pathways of T metabolism are not affected; and (2) the inducible aromatase is not sexually dimorphic in the developing brain. Since there are sex differences in adult brain aromatase, we conclude that capacity for induction of the hypothalamic aromatase becomes sexually differentiated after the post-hatching period." @default.
• W2011193016 created "2016-06-24" @default.
• W2011193016 creator A5010070272 @default.
• W2011193016 creator A5032573254 @default.
• W2011193016 date "1986-07-01" @default.
• W2011193016 modified "2023-10-17" @default.
• W2011193016 title "Testosterone induces hypothalamic aromatase during early development in quail" @default.
• W2011193016 cites W113080950 @default.
• W2011193016 cites W1242890747 @default.
• W2011193016 cites W171488037 @default.
• W2011193016 cites W187040877 @default.
• W2011193016 cites W1965577947 @default.
• W2011193016 cites W1966244177 @default.
• W2011193016 cites W1966896244 @default.
• W2011193016 cites W1967373546 @default.
• W2011193016 cites W1968492978 @default.
• W2011193016 cites W1971756437 @default.
• W2011193016 cites W1974337154 @default.
• W2011193016 cites W1982143168 @default.
• W2011193016 cites W1982478930 @default.
• W2011193016 cites W1984030659 @default.
• W2011193016 cites W1988872647 @default.
• W2011193016 cites W1991106441 @default.
• W2011193016 cites W1991190237 @default.
• W2011193016 cites W1993414583 @default.
• W2011193016 cites W1997131054 @default.
• W2011193016 cites W2005682512 @default.
• W2011193016 cites W2008711034 @default.
• W2011193016 cites W2008894026 @default.
• W2011193016 cites W2011164837 @default.
• W2011193016 cites W2014253934 @default.
• W2011193016 cites W2016343046 @default.
• W2011193016 cites W201929276 @default.
• W2011193016 cites W2022376136 @default.
• W2011193016 cites W2023976036 @default.
• W2011193016 cites W2026672898 @default.
• W2011193016 cites W2031614080 @default.
• W2011193016 cites W2032606387 @default.
• W2011193016 cites W2035475183 @default.
• W2011193016 cites W2036532998 @default.
• W2011193016 cites W2036795374 @default.
• W2011193016 cites W2038401466 @default.
• W2011193016 cites W2041873319 @default.
• W2011193016 cites W2049291829 @default.
• W2011193016 cites W2049650010 @default.
• W2011193016 cites W2052066881 @default.
• W2011193016 cites W2052435478 @default.
• W2011193016 cites W2055313051 @default.
• W2011193016 cites W2056158383 @default.
• W2011193016 cites W2057450727 @default.
• W2011193016 cites W2062731472 @default.
• W2011193016 cites W2065239243 @default.
• W2011193016 cites W2070781517 @default.
• W2011193016 cites W2080908824 @default.
• W2011193016 cites W2084529067 @default.
• W2011193016 cites W2090983810 @default.
• W2011193016 cites W2092861325 @default.
• W2011193016 cites W2094902787 @default.
• W2011193016 cites W2095182592 @default.
• W2011193016 cites W2107413237 @default.
• W2011193016 cites W2125096799 @default.
• W2011193016 cites W2128635872 @default.
• W2011193016 cites W2138916542 @default.
• W2011193016 cites W2208479771 @default.
• W2011193016 cites W2895942640 @default.
• W2011193016 cites W655263379 @default.
• W2011193016 cites W79578457 @default.
• W2011193016 cites W91809170 @default.
• W2011193016 cites W2044100755 @default.
• W2011193016 doi "https://doi.org/10.1016/0006-8993(86)91191-1" @default.
• W2011193016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3730856" @default.
• W2011193016 hasPublicationYear "1986" @default.
• W2011193016 type Work @default.
• W2011193016 sameAs 2011193016 @default.
• W2011193016 citedByCount "43" @default.
• W2011193016 countsByYear W20111930162012 @default.
• W2011193016 countsByYear W20111930162017 @default.
• W2011193016 crossrefType "journal-article" @default.
• W2011193016 hasAuthorship W2011193016A5010070272 @default.
• W2011193016 hasAuthorship W2011193016A5032573254 @default.
• W2011193016 hasConcept C121608353 @default.
• W2011193016 hasConcept C126322002 @default.
• W2011193016 hasConcept C134018914 @default.
• W2011193016 hasConcept C2776166826 @default.
• W2011193016 hasConcept C2776451244 @default.
• W2011193016 hasConcept C2777003273 @default.
• W2011193016 hasConcept C2777882087 @default.
• W2011193016 hasConcept C2777911890 @default.
• W2011193016 hasConcept C2779279991 @default.
• W2011193016 hasConcept C2779881493 @default.
• W2011193016 hasConcept C530470458 @default.
• W2011193016 hasConcept C71315377 @default.
• W2011193016 hasConcept C71924100 @default.
• W2011193016 hasConcept C86803240 @default.
• W2011193016 hasConceptScore W2011193016C121608353 @default.
• W2011193016 hasConceptScore W2011193016C126322002 @default.
• W2011193016 hasConceptScore W2011193016C134018914 @default.
• W2011193016 hasConceptScore W2011193016C2776166826 @default.

• next