FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011193995> ?p ?o ?g. }

• W2011193995 endingPage "378" @default.
• W2011193995 startingPage "378" @default.
• W2011193995 abstract "The 8th Commonwealth Congress on Diarrhoea and Malnutrition in Dhaka, Bangladesh, earlier this month questioned whether we are doing enough towards combating malnutrition and intestinal diseases in children. We could be, if recent advances in managing diarrhoea and malnutrition and in supplementing micronutrients, particularly zinc, were to be widely implemented.Most episodes of diarrhoea are infectious and are caused by a variety of bacteria, viruses, and parasites.w1 Dehydration is the most direct effect of diarrhoea, accounting for the majority of deaths. The advent and widespread adoption of oral rehydration therapy has greatly reduced the mortality related to diarrhoea.w2Yet diarrhoeal illnesses in young children continue to be a leading cause of morbidity and mortality worldwide. Every year around 10 million children under 5 die: about half of these deaths are associated with undernutrition and about 2 million with diarrhoea (out of a total of 2.5 billion episodes of diarrhoea).1 w3 Most mortality related to diarrhoea occurs in less developed countries, and the highest rates of diarrhoea occur among malnourished children.1 The case fatality rate is highest among children aged 6-12 months because at this age the immune system is not yet fully mature, maternal antibodies are waning, and the foods introduced to complement breastfeeding may be contaminated.For more than three decades an oral rehydration solution containing 90 mmol/l of sodium and 111 mmol/l of glucose has been used, saving millions of lives around the world. Recently, WHO and Unicef have recommended the use of a new reduced osmolarity formulation for oral rehydration comprising 75 mmol/l of sodium and 75 mmol/l of glucose and an osmolarity of 245 mmol/l.2 This new formulation is at least as efficacious as the standard oral rehydration solution, and a meta-analysis showed that it reduced the need for unscheduled intravenous therapy by 33%, stool output by 20%, and the incidence of vomiting by 30%.w4Although the effectiveness of oral rehydration therapy has been proved, only about 20% of children with diarrhoeal episodes worldwide currently receive it appropriately.3 Furthermore, knowledge and use of appropriate home treatments to manage diarrhoea successfully may be declining. Adherence to recommendations for children is poor because oral rehydration therapy does not reduce the duration of diarrhoea: this often leads to use of antibiotics and other treatments of no proved value. The continued high morbidity, mortality, and malnutrition associated with diarrhoeal diseases have led to a search for adjunctive treatments.Numerous randomised controlled trials have shown the therapeutic benefits of zinc supplementation during diarrhoea,w5 w6 and WHO and Unicef have recently recommended the therapeutic use of zinc for 10-14 days at a dose of 10 mg daily in infants less than 6 months old and 20 mg daily in older children.2 The effectiveness of different delivery strategies for zinc is currently being evaluated.Thus the clinical management of acute diarrhoea has four main components: replacement of ongoing losses of fluid and electrolytes, zinc therapy, antimicrobial therapy when indicated, and continued feeding to supply enough nutrients to meet both the patient's usual maintenance requirements and the increased needs imposed by infection and malabsorption.w1About 10% of diarrhoeal episodes in less developed countries lead to persistent diarrhoea of more than two weeks' duration and require specialised treatment in addition to rehydration therapy. Although dehydration is the most direct effect of diarrhoea, many other adverse and potentially fatal nutritional consequences arise in the absence of proper nutritional management. Undernutrition increases the incidence and severity of diarrhoea and diarrhoea is detrimental to nutritional status.4 Moreover, infection and micronutrient deficiencies including zinc deficiency can induce immunodeficiency in otherwise healthy children, increasing susceptibility to diarrhoea and other infections. This can lead to a vicious cycle of repeated infections, reduced immunity, and deteriorating nutritional status.5Diarrhoeal illnesses account for 10-80% of growth retardation in the first few years of life worldwide, with the magnitude of effect possibly modified by other factors such as aetiology and clinical type of diarrhoea, the source and adequacy of dietary intake, treatment, and feeding practices.6 Understanding the mechanisms of diarrhoea induced undernutrition and appropriate treatment of diarrhoea is important for managing the immediate illness and also for maximising children's wellbeing in the long term." @default.
• W2011193995 created "2016-06-24" @default.
• W2011193995 creator A5062953269 @default.
• W2011193995 creator A5084152395 @default.
• W2011193995 date "2006-02-16" @default.
• W2011193995 modified "2023-10-01" @default.
• W2011193995 title "Diarrhoea and malnutrition in children" @default.
• W2011193995 cites W1853862332 @default.
• W2011193995 cites W1895422116 @default.
• W2011193995 cites W2162334426 @default.
• W2011193995 cites W4230894813 @default.
• W2011193995 doi "https://doi.org/10.1136/bmj.332.7538.378" @default.
• W2011193995 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1370961" @default.
• W2011193995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16484244" @default.
• W2011193995 hasPublicationYear "2006" @default.
• W2011193995 type Work @default.
• W2011193995 sameAs 2011193995 @default.
• W2011193995 citedByCount "16" @default.
• W2011193995 countsByYear W20111939952012 @default.
• W2011193995 countsByYear W20111939952013 @default.
• W2011193995 countsByYear W20111939952015 @default.
• W2011193995 countsByYear W20111939952017 @default.
• W2011193995 countsByYear W20111939952019 @default.
• W2011193995 countsByYear W20111939952020 @default.
• W2011193995 countsByYear W20111939952023 @default.
• W2011193995 crossrefType "journal-article" @default.
• W2011193995 hasAuthorship W2011193995A5062953269 @default.
• W2011193995 hasAuthorship W2011193995A5084152395 @default.
• W2011193995 hasBestOaLocation W20111939952 @default.
• W2011193995 hasConcept C136764020 @default.
• W2011193995 hasConcept C142724271 @default.
• W2011193995 hasConcept C187212893 @default.
• W2011193995 hasConcept C2522767166 @default.
• W2011193995 hasConcept C2779802037 @default.
• W2011193995 hasConcept C2908544876 @default.
• W2011193995 hasConcept C2908647359 @default.
• W2011193995 hasConcept C2986817661 @default.
• W2011193995 hasConcept C41008148 @default.
• W2011193995 hasConcept C551997983 @default.
• W2011193995 hasConcept C71924100 @default.
• W2011193995 hasConcept C99454951 @default.
• W2011193995 hasConceptScore W2011193995C136764020 @default.
• W2011193995 hasConceptScore W2011193995C142724271 @default.
• W2011193995 hasConceptScore W2011193995C187212893 @default.
• W2011193995 hasConceptScore W2011193995C2522767166 @default.
• W2011193995 hasConceptScore W2011193995C2779802037 @default.
• W2011193995 hasConceptScore W2011193995C2908544876 @default.
• W2011193995 hasConceptScore W2011193995C2908647359 @default.
• W2011193995 hasConceptScore W2011193995C2986817661 @default.
• W2011193995 hasConceptScore W2011193995C41008148 @default.
• W2011193995 hasConceptScore W2011193995C551997983 @default.
• W2011193995 hasConceptScore W2011193995C71924100 @default.
• W2011193995 hasConceptScore W2011193995C99454951 @default.
• W2011193995 hasIssue "7538" @default.
• W2011193995 hasLocation W20111939951 @default.
• W2011193995 hasLocation W20111939952 @default.
• W2011193995 hasLocation W20111939953 @default.
• W2011193995 hasLocation W20111939954 @default.
• W2011193995 hasOpenAccess W2011193995 @default.
• W2011193995 hasPrimaryLocation W20111939951 @default.
• W2011193995 hasRelatedWork W1656458946 @default.
• W2011193995 hasRelatedWork W1948634989 @default.
• W2011193995 hasRelatedWork W1959965249 @default.
• W2011193995 hasRelatedWork W2167981913 @default.
• W2011193995 hasRelatedWork W2171447947 @default.
• W2011193995 hasRelatedWork W2210227844 @default.
• W2011193995 hasRelatedWork W2748952813 @default.
• W2011193995 hasRelatedWork W4366413231 @default.
• W2011193995 hasRelatedWork W2187743234 @default.
• W2011193995 hasRelatedWork W2598691266 @default.
• W2011193995 hasVolume "332" @default.
• W2011193995 isParatext "false" @default.
• W2011193995 isRetracted "false" @default.
• W2011193995 magId "2011193995" @default.
• W2011193995 workType "article" @default.