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- W2011195003 abstract "Abstract Asphyxia during delivery produces long‐term deficits in brain development, including hippocampus. We investigated hippocampal plasticity after perinatal asphyxia, measuring postnatal apoptosis and neurogenesis. Asphyxia was performed by immersing rat fetuses with uterine horns removed from ready‐to‐deliver rats into a water bath for 20 min. Caesarean‐delivered pups were used as controls. The animals were euthanized 1 week or 1 month after birth. Apoptotic nuclear morphology and DNA breaks were assessed by Hoechst and TUNEL assays. Neurogenesis was estimated by bromodeoxyuridine/MAP‐2 immunocytochemitry, and the levels and expression of proteins related to apoptosis and cell proliferation were measured by Western blots and in situ hybridization, respectively. There was an increase of apoptosis in CA1, CA3, and dentate gyrus (DG) and cell proliferation and neurogenesis in CA1, DG, and hilus regions of hippocampus 1 week after asphyxia. The increase of apoptosis in CA3 and cell proliferation in the suprapyramidal band of DG was still observed 1 month following asphyxia. There was an increase of BAD, BCL‐2, ERK2, and bFGF levels in whole hippocampus and bFGF expression in CA1 and CA2 and hilus at P7 and P30. There was a concomitant decrease of phosphorylated‐BAD (Ser112) levels. The increase of BAD levels supports the idea of delayed cell death after perinatal asphyxia, whereas the increases of BCL‐2, ERK2, and bFGF levels suggest the activation of neuroprotective and repair pathways. In conclusion, perinatal asphyxia induces short‐ and long‐term regionally specific plastic changes, including delayed cell death and neurogenesis, involving pro‐ and antiapoptotic as well as mitogenic proteins, favoring hippocampal functional recovery. © 2008 Wiley‐Liss, Inc." @default.
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- W2011195003 date "2008-05-30" @default.
- W2011195003 modified "2023-10-18" @default.
- W2011195003 title "Plasticity of hippocampus following perinatal asphyxia: Effects on postnatal apoptosis and neurogenesis" @default.
- W2011195003 cites W1480948328 @default.
- W2011195003 cites W1482301804 @default.
- W2011195003 cites W1529233910 @default.
- W2011195003 cites W1540436551 @default.
- W2011195003 cites W1549794846 @default.
- W2011195003 cites W1566676785 @default.
- W2011195003 cites W1586118899 @default.
- W2011195003 cites W1901072277 @default.
- W2011195003 cites W1913938270 @default.
- W2011195003 cites W1964591117 @default.
- W2011195003 cites W1965776495 @default.
- W2011195003 cites W1966281858 @default.
- W2011195003 cites W1966403764 @default.
- W2011195003 cites W1966578525 @default.
- W2011195003 cites W1966638035 @default.
- W2011195003 cites W1971557664 @default.
- W2011195003 cites W1971811708 @default.
- W2011195003 cites W1973404900 @default.
- W2011195003 cites W1974426595 @default.
- W2011195003 cites W1975823509 @default.
- W2011195003 cites W1977182713 @default.
- W2011195003 cites W1977472414 @default.
- W2011195003 cites W1978559408 @default.
- W2011195003 cites W1980322487 @default.
- W2011195003 cites W1983112915 @default.
- W2011195003 cites W1987169758 @default.
- W2011195003 cites W1989954752 @default.
- W2011195003 cites W1991505454 @default.
- W2011195003 cites W1992463891 @default.
- W2011195003 cites W1993206887 @default.
- W2011195003 cites W1995505431 @default.
- W2011195003 cites W1995557342 @default.
- W2011195003 cites W1996993676 @default.
- W2011195003 cites W1997318723 @default.
- W2011195003 cites W1997342733 @default.
- W2011195003 cites W1998040264 @default.
- W2011195003 cites W1999582449 @default.
- W2011195003 cites W2001990792 @default.
- W2011195003 cites W2003085407 @default.
- W2011195003 cites W2004568898 @default.
- W2011195003 cites W2007129666 @default.
- W2011195003 cites W2007261940 @default.
- W2011195003 cites W2007486260 @default.
- W2011195003 cites W2008372946 @default.
- W2011195003 cites W2008566143 @default.
- W2011195003 cites W2009653945 @default.
- W2011195003 cites W2011605975 @default.
- W2011195003 cites W2012797849 @default.
- W2011195003 cites W2014718655 @default.
- W2011195003 cites W2021235898 @default.
- W2011195003 cites W2022621601 @default.
- W2011195003 cites W2023301616 @default.
- W2011195003 cites W2029429092 @default.
- W2011195003 cites W2032200023 @default.
- W2011195003 cites W2034128098 @default.
- W2011195003 cites W2035172569 @default.
- W2011195003 cites W2037695401 @default.
- W2011195003 cites W2038418713 @default.
- W2011195003 cites W2039876247 @default.
- W2011195003 cites W2043758600 @default.
- W2011195003 cites W2044311066 @default.
- W2011195003 cites W2044357647 @default.
- W2011195003 cites W2049020054 @default.
- W2011195003 cites W2051881152 @default.
- W2011195003 cites W2056944545 @default.
- W2011195003 cites W2057056489 @default.
- W2011195003 cites W2057713336 @default.
- W2011195003 cites W2058488747 @default.
- W2011195003 cites W2068412840 @default.
- W2011195003 cites W2071763011 @default.
- W2011195003 cites W2072252062 @default.
- W2011195003 cites W2075026191 @default.
- W2011195003 cites W2076308773 @default.
- W2011195003 cites W2086262311 @default.
- W2011195003 cites W2089071506 @default.
- W2011195003 cites W2089825255 @default.
- W2011195003 cites W2093628776 @default.
- W2011195003 cites W2103131046 @default.
- W2011195003 cites W2105382539 @default.
- W2011195003 cites W2111262048 @default.
- W2011195003 cites W2116765510 @default.
- W2011195003 cites W2117703821 @default.
- W2011195003 cites W2130374291 @default.
- W2011195003 cites W2132823130 @default.