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- W2011196310 abstract "Proceedings: AACR 101st Annual Meeting 2010‐‐ Apr 17‐21, 2010; Washington, DCHuman arrest defective 1 protein, ARD1, is an N-acetyltransferase known to be involved in cell cycle control. We found that ARD1 is highly expressed in the early stage of the cell cycle and less highly expressed in a variety of human malignancies that metastasize to lymph nodes. ARD1 expression favors survival in patients. ARD1 significantly suppressed migration, tumor growth, and metastasis independent of its enzymatic activity. Instead, ARD1 binds to the GIT-binding domain of PIX, thereby preventing the formation of the GIT-PIX-Paxillin complex, resulting in reduced intrinsic Cdc42/Rac1 activities and decreased cell migration. Forced expression of PIX in ARD1-transfected tumor cells restored the migration and metastasis ability. We suggest that ARD1 functions as a novel tumor metastasis suppressor by disrupting the migratory complex, GIT-PIX-Paxillin, in cancer cells.Note: This abstract was not presented at the AACR 101st Annual Meeting 2010 because the presenter was unable to attend.Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 3376." @default.
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- W2011196310 date "2010-04-15" @default.
- W2011196310 modified "2023-09-25" @default.
- W2011196310 title "Abstract 3376: Human arrest defective 1 protein suppresses cancer cell metastasis by binding PIX/Cool proteins and inhibiting Cdc42/Rac1 activity" @default.
- W2011196310 doi "https://doi.org/10.1158/1538-7445.am10-3376" @default.
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