Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011197811> ?p ?o ?g. }
- W2011197811 endingPage "4589" @default.
- W2011197811 startingPage "4581" @default.
- W2011197811 abstract "Membrane recruitment of the SH2containing 5′ inositol phosphatase 1 (SHIP-1) is responsible for the inhibitory signals that modulate phosphatidylinositol 3-kinase (PI3K)–dependent signaling pathways. Here we have investigated the molecular mechanisms underlying SHIP-1 activation and its role in CD16-mediated cytotoxicity. We initially demonstrated that a substantial fraction of SHIP-1–mediated 5′ inositol phosphatase activity associates with CD16 ζ chain after receptor cross-linking. Moreover, CD16 stimulation on human primary natural killer (NK) cells induces the rapid and transient translocation of SHIP-1 in the lipid-enriched plasma membrane microdomains, termed rafts, where it associates with tyrosine-phosphorylated ζ chain and shc adaptor protein. As evaluated by confocal microscopy, CD16 engagement by reverse antibody-dependent cellular cytotoxicity (ADCC) rapidly induces SHIP-1 redistribution toward the area of NK cell contact with target cells and its codistribution with aggregated rafts where CD16 receptor also colocalizes. The functional role of SHIP-1 in the modulation of CD16-induced cytotoxicity was explored in NK cells infected with recombinant vaccinia viruses encoding wild-type or catalytic domain–deleted mutant SHIP-1. We found a significant SHIP-1–mediated decrease of CD16-induced cytotoxicity that is strictly dependent on its catalytic activity. These data demonstrate that CD16 engagement on NK cells induces membrane targeting and activation of SHIP-1, which acts as negative regulator of ADCC function." @default.
- W2011197811 created "2016-06-24" @default.
- W2011197811 creator A5002208966 @default.
- W2011197811 creator A5003992747 @default.
- W2011197811 creator A5016796885 @default.
- W2011197811 creator A5024871281 @default.
- W2011197811 creator A5045719432 @default.
- W2011197811 creator A5055250426 @default.
- W2011197811 creator A5089265409 @default.
- W2011197811 date "2002-12-15" @default.
- W2011197811 modified "2023-10-11" @default.
- W2011197811 title "SH2-containing inositol phosphatase (SHIP-1) transiently translocates to raft domains and modulates CD16-mediated cytotoxicity in human NK cells" @default.
- W2011197811 cites W1499222468 @default.
- W2011197811 cites W1560450744 @default.
- W2011197811 cites W1564861448 @default.
- W2011197811 cites W1604829025 @default.
- W2011197811 cites W1608613084 @default.
- W2011197811 cites W1751582242 @default.
- W2011197811 cites W1755060294 @default.
- W2011197811 cites W1891201198 @default.
- W2011197811 cites W1966930760 @default.
- W2011197811 cites W1972145067 @default.
- W2011197811 cites W1975987716 @default.
- W2011197811 cites W1976255260 @default.
- W2011197811 cites W1985898120 @default.
- W2011197811 cites W1990246525 @default.
- W2011197811 cites W1997747159 @default.
- W2011197811 cites W2004756723 @default.
- W2011197811 cites W2005131087 @default.
- W2011197811 cites W2011870840 @default.
- W2011197811 cites W2021406365 @default.
- W2011197811 cites W2022451156 @default.
- W2011197811 cites W2054697569 @default.
- W2011197811 cites W2056206771 @default.
- W2011197811 cites W2068504553 @default.
- W2011197811 cites W2071981946 @default.
- W2011197811 cites W2072341414 @default.
- W2011197811 cites W2089778667 @default.
- W2011197811 cites W2106994186 @default.
- W2011197811 cites W2113009216 @default.
- W2011197811 cites W2115037258 @default.
- W2011197811 cites W2116364705 @default.
- W2011197811 cites W2122652506 @default.
- W2011197811 cites W2127141367 @default.
- W2011197811 cites W2130649175 @default.
- W2011197811 cites W2132264213 @default.
- W2011197811 cites W2135077731 @default.
- W2011197811 cites W2148242087 @default.
- W2011197811 cites W2150054315 @default.
- W2011197811 cites W2154161087 @default.
- W2011197811 cites W2161261440 @default.
- W2011197811 cites W2162332365 @default.
- W2011197811 cites W2164139183 @default.
- W2011197811 cites W2165742826 @default.
- W2011197811 cites W2408199952 @default.
- W2011197811 doi "https://doi.org/10.1182/blood-2002-04-1058" @default.
- W2011197811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12393695" @default.
- W2011197811 hasPublicationYear "2002" @default.
- W2011197811 type Work @default.
- W2011197811 sameAs 2011197811 @default.
- W2011197811 citedByCount "69" @default.
- W2011197811 countsByYear W20111978112012 @default.
- W2011197811 countsByYear W20111978112013 @default.
- W2011197811 countsByYear W20111978112014 @default.
- W2011197811 countsByYear W20111978112015 @default.
- W2011197811 countsByYear W20111978112017 @default.
- W2011197811 countsByYear W20111978112018 @default.
- W2011197811 countsByYear W20111978112019 @default.
- W2011197811 countsByYear W20111978112020 @default.
- W2011197811 countsByYear W20111978112021 @default.
- W2011197811 countsByYear W20111978112022 @default.
- W2011197811 crossrefType "journal-article" @default.
- W2011197811 hasAuthorship W2011197811A5002208966 @default.
- W2011197811 hasAuthorship W2011197811A5003992747 @default.
- W2011197811 hasAuthorship W2011197811A5016796885 @default.
- W2011197811 hasAuthorship W2011197811A5024871281 @default.
- W2011197811 hasAuthorship W2011197811A5045719432 @default.
- W2011197811 hasAuthorship W2011197811A5055250426 @default.
- W2011197811 hasAuthorship W2011197811A5089265409 @default.
- W2011197811 hasBestOaLocation W20111978111 @default.
- W2011197811 hasConcept C109316439 @default.
- W2011197811 hasConcept C114684123 @default.
- W2011197811 hasConcept C11960822 @default.
- W2011197811 hasConcept C147483822 @default.
- W2011197811 hasConcept C167672396 @default.
- W2011197811 hasConcept C202751555 @default.
- W2011197811 hasConcept C203014093 @default.
- W2011197811 hasConcept C2777553839 @default.
- W2011197811 hasConcept C2781462264 @default.
- W2011197811 hasConcept C40677261 @default.
- W2011197811 hasConcept C55493867 @default.
- W2011197811 hasConcept C62478195 @default.
- W2011197811 hasConcept C79266657 @default.
- W2011197811 hasConcept C86803240 @default.
- W2011197811 hasConcept C95444343 @default.
- W2011197811 hasConceptScore W2011197811C109316439 @default.
- W2011197811 hasConceptScore W2011197811C114684123 @default.
- W2011197811 hasConceptScore W2011197811C11960822 @default.