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• W2011199056 abstract "Several studies have reported an association of the apolipoprotein E allele ε4 (APOE*4) to familial and sporadic late-onset Alzheimer's disease (LOAD). Here we report on the relationship between APOE*4 and early-onset Alzheimer's disease (EOAD) in a Dutch population-based study. The frequency of the APOE*4 allele was 2.3 times higher among EOAD cases compared to controls. Among patients, the allele frequency was 1.6 times higher in those with a positive family history than in those without. A significant increase in risk of EOAD was found for subjects homozygous for APOE*4 regardless of family history of dementia, but an increase in EOAD risk for APOE*4 heterozygotes could only be shown in subjects with a positive family history. Our study demonstrates a significant association between APOE*4 and EOAD which is modified by family history of dementia." @default.
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• W2011199056 date "1994-05-01" @default.
• W2011199056 modified "2023-10-16" @default.
• W2011199056 title "Apolipoprotein E4 allele in a population–based study of early–onset Alzheimer's disease" @default.
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• W2011199056 doi "https://doi.org/10.1038/ng0594-74" @default.
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