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• W2011199125 abstract "Malignant hyperthermia-susceptible (MHS) pigs express a sarcoplasmic reticulum (SR) Ca2+-release channel mutation that results in lower than normal contractile thresholds in skeletal muscles. In adult MHS pig muscles the L-type calcium current (Is) is also reduced. We tested the hypothesis that there is a causal relationship between Is and the lower contractile threshold by recording Is from MHs and normal porcine myotubes using the whole cell patch-clamp technique. Current voltage relationships for both MHS and normal myotubes were similar, with peak Is between +20 and +30 mV. Maximum Is amplitudes were not different (normal: 4976 ± 566 pA; MHS: 6516 ± 1088 pA) nor was Is specific density (normal: 9.0 ± 0.8; MHS: 8.8 ± 1.1 pA/pF). In both MHS and normal myotubes, both the dihydropyridine antagonist PN200 –110 (200 nmol/L) and holding the membrane potential at −10 mV for 5 min decreased Is significantly (by more than 50%). There was no apparent direct relationship between the mutation in the SR Ca2+-release channel and lowered Is. We concluded that reduced Is in adult MHS pig muscles may be a secondary effect of the SR Ca2+-release channel mutation on muscle development. © 1996 John Wiley & Sons, Inc." @default.
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• W2011199125 date "1996-04-01" @default.
• W2011199125 modified "2023-09-23" @default.
• W2011199125 title "Slow calcium current is not reduced in malignant hyperthermic porcine myotubes" @default.
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• W2011199125 doi "https://doi.org/10.1002/(sici)1097-4598(199604)19:4<450::aid-mus4>3.0.co;2-b" @default.
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