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• W2011199617 abstract "Summary Background : The incidence of Barrett's oesophageal adenocarcinoma is increasing more rapidly than any other malignancy in industrialized countries. Cyclo‐oxygenase‐2 appears to play an important role in gastrointestinal carcinogenesis. Previous studies on cyclo‐oxygenase‐2 expression in Barrett's oesophageal carcinogenesis have utilized tissue samples obtained from different patients. We sought a definitive comparison of cyclo‐oxygenase‐2 expression in the sequence of Barrett's metaplasia–dysplasia–adenocarcinoma within the same patients. Methods : Paraffin‐embedded oesophago‐gastrectomy specimens from 20 patients, containing successive stages of Barrett's metaplasia, high‐grade dysplasia and adenocarcinoma, were analysed for cyclo‐oxygenase‐2 expression by immunohistochemistry. Results : Cyclo‐oxygenase‐2 was constitutively expressed in the basal layers of cells in the adjacent normal squamous oesophageal epithelium, but a higher cyclo‐oxygenase‐2 expression was observed in Barrett's metaplasia. A further increase in cyclo‐oxygenase‐2 expression was detected in high‐grade dysplasia, but cyclo‐oxygenase‐2 was decreased in adenocarcinoma tissue, regardless of its stage or level of differentiation. Conclusions : Cyclo‐oxygenase‐2 expression is progressively increased when squamous oesophageal epithelium develops into Barrett's metaplastic epithelium and then into high‐grade dysplasia, but appears to decrease when adenocarcinoma develops. These findings may be significant for an effective chemo‐prevention strategy with selective cyclo‐oxygenase‐2 inhibitors." @default.
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• W2011199617 date "2003-02-01" @default.
• W2011199617 modified "2023-10-14" @default.
• W2011199617 title "Cyclo-oxygenase-2 expression in Barrett's oesophageal carcinogenesis: an immunohistochemical study" @default.
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• W2011199617 doi "https://doi.org/10.1046/j.1365-2036.2003.01432.x" @default.
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