Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011205507> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2011205507 endingPage "984" @default.
- W2011205507 startingPage "969" @default.
- W2011205507 abstract "1. The defects produced on the membrane of the human red blood cell by the action of complement and antibody have been studied by the use of the electron microscope. These are round to slightly ovoid holes and are surrounded by an irregular ring, about 20 A thick. The mean diameter of the holes is about 103 A if human complement is used (regardless of the antibody used for sensitization) and about 88 A if guinea pig complement is used. 2. The holes in normal and PNH red cells appear to be identical, under the same conditions. The membrane defects produced by lysis of PNH cells with acidified normal serum (the Ham's test) are identical to those produced by complement lysis with specific antibody, indicating that complement is undoubtedly the cause of such lysis. 3. Evidence is presented that when human complement acts on human red cells sensitized with anti-I antibody, each complete activation of complement leads to the production of a cluster of holes. This contrasts to the action of guinea pig complement, on sheep cells, each activation of which leads to a single hole. 4. The maximum number of anti-I antibody molecules which can attach to a human red cell (i.e. the minimum number of antigen sites) is about 500,000 for both normal and PNH cells. 5. The number of holes produced during lysis of the PNH cell is the same as that of the normal cell. When all cells are lysed by am excess of C', a mean of about 90,000 holes are present on each membrane. When complement is limited, a larger proportion of PNH cells are lysed due to their peculiar sensitivity to C' but the number of holes on each lysed cell is the same as for normal cells lysed by the same concentration of C'." @default.
- W2011205507 created "2016-06-24" @default.
- W2011205507 creator A5065185251 @default.
- W2011205507 creator A5071776286 @default.
- W2011205507 creator A5086924717 @default.
- W2011205507 date "1966-06-01" @default.
- W2011205507 modified "2023-09-24" @default.
- W2011205507 title "IMMUNE LYSIS OF NORMAL HUMAN AND PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH) RED BLOOD CELLS" @default.
- W2011205507 cites W1495715079 @default.
- W2011205507 cites W1953095122 @default.
- W2011205507 cites W1974771467 @default.
- W2011205507 cites W1979083355 @default.
- W2011205507 cites W1989641725 @default.
- W2011205507 cites W2007829400 @default.
- W2011205507 cites W2029177439 @default.
- W2011205507 cites W2032838364 @default.
- W2011205507 cites W2032984366 @default.
- W2011205507 cites W2042752766 @default.
- W2011205507 cites W2085947198 @default.
- W2011205507 cites W2246863017 @default.
- W2011205507 doi "https://doi.org/10.1084/jem.123.6.969" @default.
- W2011205507 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2138177" @default.
- W2011205507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5941785" @default.
- W2011205507 hasPublicationYear "1966" @default.
- W2011205507 type Work @default.
- W2011205507 sameAs 2011205507 @default.
- W2011205507 citedByCount "58" @default.
- W2011205507 countsByYear W20112055072013 @default.
- W2011205507 countsByYear W20112055072019 @default.
- W2011205507 countsByYear W20112055072020 @default.
- W2011205507 crossrefType "journal-article" @default.
- W2011205507 hasAuthorship W2011205507A5065185251 @default.
- W2011205507 hasAuthorship W2011205507A5071776286 @default.
- W2011205507 hasAuthorship W2011205507A5086924717 @default.
- W2011205507 hasBestOaLocation W20112055071 @default.
- W2011205507 hasConcept C109316439 @default.
- W2011205507 hasConcept C111684460 @default.
- W2011205507 hasConcept C147483822 @default.
- W2011205507 hasConcept C153911025 @default.
- W2011205507 hasConcept C159654299 @default.
- W2011205507 hasConcept C185592680 @default.
- W2011205507 hasConcept C202751555 @default.
- W2011205507 hasConcept C203014093 @default.
- W2011205507 hasConcept C2777346216 @default.
- W2011205507 hasConcept C2778212101 @default.
- W2011205507 hasConcept C2779902561 @default.
- W2011205507 hasConcept C34343649 @default.
- W2011205507 hasConcept C55493867 @default.
- W2011205507 hasConcept C57409179 @default.
- W2011205507 hasConcept C73588182 @default.
- W2011205507 hasConcept C86803240 @default.
- W2011205507 hasConcept C8891405 @default.
- W2011205507 hasConceptScore W2011205507C109316439 @default.
- W2011205507 hasConceptScore W2011205507C111684460 @default.
- W2011205507 hasConceptScore W2011205507C147483822 @default.
- W2011205507 hasConceptScore W2011205507C153911025 @default.
- W2011205507 hasConceptScore W2011205507C159654299 @default.
- W2011205507 hasConceptScore W2011205507C185592680 @default.
- W2011205507 hasConceptScore W2011205507C202751555 @default.
- W2011205507 hasConceptScore W2011205507C203014093 @default.
- W2011205507 hasConceptScore W2011205507C2777346216 @default.
- W2011205507 hasConceptScore W2011205507C2778212101 @default.
- W2011205507 hasConceptScore W2011205507C2779902561 @default.
- W2011205507 hasConceptScore W2011205507C34343649 @default.
- W2011205507 hasConceptScore W2011205507C55493867 @default.
- W2011205507 hasConceptScore W2011205507C57409179 @default.
- W2011205507 hasConceptScore W2011205507C73588182 @default.
- W2011205507 hasConceptScore W2011205507C86803240 @default.
- W2011205507 hasConceptScore W2011205507C8891405 @default.
- W2011205507 hasIssue "6" @default.
- W2011205507 hasLocation W20112055071 @default.
- W2011205507 hasLocation W20112055072 @default.
- W2011205507 hasLocation W20112055073 @default.
- W2011205507 hasLocation W20112055074 @default.
- W2011205507 hasOpenAccess W2011205507 @default.
- W2011205507 hasPrimaryLocation W20112055071 @default.
- W2011205507 hasRelatedWork W1550728793 @default.
- W2011205507 hasRelatedWork W1551361242 @default.
- W2011205507 hasRelatedWork W1777690075 @default.
- W2011205507 hasRelatedWork W189181064 @default.
- W2011205507 hasRelatedWork W1928671008 @default.
- W2011205507 hasRelatedWork W1980755391 @default.
- W2011205507 hasRelatedWork W2064531807 @default.
- W2011205507 hasRelatedWork W2072699269 @default.
- W2011205507 hasRelatedWork W2085759307 @default.
- W2011205507 hasRelatedWork W4251174821 @default.
- W2011205507 hasVolume "123" @default.
- W2011205507 isParatext "false" @default.
- W2011205507 isRetracted "false" @default.
- W2011205507 magId "2011205507" @default.
- W2011205507 workType "article" @default.