FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011216638> ?p ?o ?g. }

• W2011216638 endingPage "384" @default.
• W2011216638 startingPage "377" @default.
• W2011216638 abstract "The focus of this study is to determine both mRNA and protein expression levels of the type I interferon (IFN) receptor subunits, IFNalpha receptor (IFNAR1) and IFNalpha/beta receptor (IFNAR2), in the liver, and to assess which quantification method is most useful in predicting response to IFN in chronic hepatitis C patients. Liver biopsy specimens from 41 chronic hepatitis C patients subsequently treated with IFN were immunostained with IFNAR1 and IFNAR2 antibodies, and also analyzed for both receptor subunit mRNA levels, using competitive polymerase chain reaction. Immunostaining of IFNAR1 and IFNAR2 was observed in the cell membrane and cytoplasm of hepatocytes in all liver specimens. Hepatic expression of IFNAR1 (r=0.45, P=0.012) or IFNAR2 mRNA (r=0.46, P=0.009) was weakly correlated with their protein expression in hepatocytes. The labeling indexes of IFNAR1 (136.7+/-94.1 vs. 77.4+/-76.8, P=0.032) and IFNAR2 (153.1+/-80.2 vs. 87.2+/-75.5, P=0.011) in liver specimens were significantly higher in sustained virologic responders (n=17) than in non-sustained virologic responders (n=24), while mRNA levels of either receptor subunit did not differ between response groups. These results suggest that protein expression of the type I IFN receptor in liver is a more useful measure than its mRNA expression in predicting response to IFN in chronic hepatitis C patients." @default.
• W2011216638 created "2016-06-24" @default.
• W2011216638 creator A5004555317 @default.
• W2011216638 creator A5014005518 @default.
• W2011216638 creator A5020761729 @default.
• W2011216638 creator A5024080424 @default.
• W2011216638 creator A5025371497 @default.
• W2011216638 creator A5063755654 @default.
• W2011216638 creator A5077091934 @default.
• W2011216638 creator A5078675787 @default.
• W2011216638 date "2003-04-01" @default.
• W2011216638 modified "2023-09-26" @default.
• W2011216638 title "Hepatic expression of type I interferon receptor for predicting response to interferon therapy in chronic hepatitis C patients: a comparison of immunohistochemical method vs. competitive polymerase chain reaction assay" @default.
• W2011216638 cites W1526112170 @default.
• W2011216638 cites W1554187319 @default.
• W2011216638 cites W1830966545 @default.
• W2011216638 cites W1932223319 @default.
• W2011216638 cites W1968036302 @default.
• W2011216638 cites W1979065792 @default.
• W2011216638 cites W1996366808 @default.
• W2011216638 cites W2006061341 @default.
• W2011216638 cites W2015916009 @default.
• W2011216638 cites W2018772554 @default.
• W2011216638 cites W2019943793 @default.
• W2011216638 cites W2027571985 @default.
• W2011216638 cites W2034864405 @default.
• W2011216638 cites W2036120932 @default.
• W2011216638 cites W2040427873 @default.
• W2011216638 cites W2042511952 @default.
• W2011216638 cites W2057381677 @default.
• W2011216638 cites W2061742047 @default.
• W2011216638 cites W2067309227 @default.
• W2011216638 cites W2075256922 @default.
• W2011216638 cites W2088988430 @default.
• W2011216638 cites W2100848779 @default.
• W2011216638 cites W2126008417 @default.
• W2011216638 cites W2159954692 @default.
• W2011216638 cites W2168857106 @default.
• W2011216638 cites W2335845212 @default.
• W2011216638 doi "https://doi.org/10.1016/s1386-6346(02)00312-1" @default.
• W2011216638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12699848" @default.
• W2011216638 hasPublicationYear "2003" @default.
• W2011216638 type Work @default.
• W2011216638 sameAs 2011216638 @default.
• W2011216638 citedByCount "10" @default.
• W2011216638 countsByYear W20112166382012 @default.
• W2011216638 crossrefType "journal-article" @default.
• W2011216638 hasAuthorship W2011216638A5004555317 @default.
• W2011216638 hasAuthorship W2011216638A5014005518 @default.
• W2011216638 hasAuthorship W2011216638A5020761729 @default.
• W2011216638 hasAuthorship W2011216638A5024080424 @default.
• W2011216638 hasAuthorship W2011216638A5025371497 @default.
• W2011216638 hasAuthorship W2011216638A5063755654 @default.
• W2011216638 hasAuthorship W2011216638A5077091934 @default.
• W2011216638 hasAuthorship W2011216638A5078675787 @default.
• W2011216638 hasConcept C104292427 @default.
• W2011216638 hasConcept C104317684 @default.
• W2011216638 hasConcept C105580179 @default.
• W2011216638 hasConcept C126322002 @default.
• W2011216638 hasConcept C153911025 @default.
• W2011216638 hasConcept C170493617 @default.
• W2011216638 hasConcept C203014093 @default.
• W2011216638 hasConcept C204232928 @default.
• W2011216638 hasConcept C2775934546 @default.
• W2011216638 hasConcept C2776178377 @default.
• W2011216638 hasConcept C2776455275 @default.
• W2011216638 hasConcept C2777766500 @default.
• W2011216638 hasConcept C2909179924 @default.
• W2011216638 hasConcept C4224716 @default.
• W2011216638 hasConcept C48023723 @default.
• W2011216638 hasConcept C55493867 @default.
• W2011216638 hasConcept C71924100 @default.
• W2011216638 hasConcept C86803240 @default.
• W2011216638 hasConceptScore W2011216638C104292427 @default.
• W2011216638 hasConceptScore W2011216638C104317684 @default.
• W2011216638 hasConceptScore W2011216638C105580179 @default.
• W2011216638 hasConceptScore W2011216638C126322002 @default.
• W2011216638 hasConceptScore W2011216638C153911025 @default.
• W2011216638 hasConceptScore W2011216638C170493617 @default.
• W2011216638 hasConceptScore W2011216638C203014093 @default.
• W2011216638 hasConceptScore W2011216638C204232928 @default.
• W2011216638 hasConceptScore W2011216638C2775934546 @default.
• W2011216638 hasConceptScore W2011216638C2776178377 @default.
• W2011216638 hasConceptScore W2011216638C2776455275 @default.
• W2011216638 hasConceptScore W2011216638C2777766500 @default.
• W2011216638 hasConceptScore W2011216638C2909179924 @default.
• W2011216638 hasConceptScore W2011216638C4224716 @default.
• W2011216638 hasConceptScore W2011216638C48023723 @default.
• W2011216638 hasConceptScore W2011216638C55493867 @default.
• W2011216638 hasConceptScore W2011216638C71924100 @default.
• W2011216638 hasConceptScore W2011216638C86803240 @default.
• W2011216638 hasIssue "4" @default.
• W2011216638 hasLocation W20112166381 @default.
• W2011216638 hasLocation W20112166382 @default.
• W2011216638 hasOpenAccess W2011216638 @default.
• W2011216638 hasPrimaryLocation W20112166381 @default.
• W2011216638 hasRelatedWork W1892046701 @default.
• W2011216638 hasRelatedWork W1970839348 @default.

• next