FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011226248> ?p ?o ?g. }

• W2011226248 endingPage "e1001420" @default.
• W2011226248 startingPage "e1001420" @default.
• W2011226248 abstract "Background Herpes zoster is common and has serious consequences, notably post-herpetic neuralgia (PHN). Vaccine efficacy against incident zoster and PHN has been demonstrated in clinical trials, but effectiveness has not been studied in unselected general populations unrestricted by region, full health insurance coverage, or immune status. Our objective was to assess zoster vaccine effectiveness (VE) against incident zoster and PHN in a general population-based setting. Methods and Findings A cohort study of 766,330 fully eligible individuals aged ≥65 years was undertaken in a 5% random sample of Medicare who received and did not receive zoster vaccination between 1st January 2007 and 31st December 2009. Incidence rates and hazard ratios for zoster and PHN were determined in vaccinated and unvaccinated individuals. Analyses were adjusted for age, gender, race, low income, immunosuppression, and important comorbidities associated with zoster, and then stratified by immunosuppression status. Adjusted hazard ratios were estimated using time-updated Cox proportional hazards models. Vaccine uptake was low (3.9%) particularly among black people (0.3%) and those with evidence of low income (0.6%). 13,112 US Medicare beneficiaries developed incident zoster; the overall zoster incidence rate was 10.0 (9.8–10.2) per 1,000 person-years in the unvaccinated group and 5.4 (95% CI 4.6–6.4) per 1,000 person-years in vaccinees, giving an adjusted VE against incident zoster of 0.48 (95% CI 0.39–0.56). In immunosuppressed individuals, VE against zoster was 0.37 (95% CI 0.06–0.58). VE against PHN was 0.59 (95% CI 0.21–0.79). Conclusions Vaccine uptake was low with variation in specific patient groups. In a general population cohort of older individuals, zoster vaccination was associated with reduction in incident zoster, including among those with immunosuppression. Importantly, this study demonstrates that zoster vaccination is associated with a reduction in PHN. Please see later in the article for the Editors' Summary" @default.
• W2011226248 created "2016-06-24" @default.
• W2011226248 creator A5000557894 @default.
• W2011226248 creator A5022288501 @default.
• W2011226248 creator A5057661348 @default.
• W2011226248 creator A5079431219 @default.
• W2011226248 date "2013-04-09" @default.
• W2011226248 modified "2023-10-18" @default.
• W2011226248 title "Herpes Zoster Vaccine Effectiveness against Incident Herpes Zoster and Post-herpetic Neuralgia in an Older US Population: A Cohort Study" @default.
• W2011226248 cites W1967331460 @default.
• W2011226248 cites W1970558739 @default.
• W2011226248 cites W1980229960 @default.
• W2011226248 cites W2023954230 @default.
• W2011226248 cites W2075994714 @default.
• W2011226248 cites W2086658590 @default.
• W2011226248 cites W2094455504 @default.
• W2011226248 cites W2104543475 @default.
• W2011226248 cites W2113550278 @default.
• W2011226248 cites W2131041950 @default.
• W2011226248 cites W2132226325 @default.
• W2011226248 cites W2141921379 @default.
• W2011226248 cites W2149820050 @default.
• W2011226248 cites W2152734304 @default.
• W2011226248 cites W2164445871 @default.
• W2011226248 doi "https://doi.org/10.1371/journal.pmed.1001420" @default.
• W2011226248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3621740" @default.
• W2011226248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23585738" @default.
• W2011226248 hasPublicationYear "2013" @default.
• W2011226248 type Work @default.
• W2011226248 sameAs 2011226248 @default.
• W2011226248 citedByCount "181" @default.
• W2011226248 countsByYear W20112262482013 @default.
• W2011226248 countsByYear W20112262482014 @default.
• W2011226248 countsByYear W20112262482015 @default.
• W2011226248 countsByYear W20112262482016 @default.
• W2011226248 countsByYear W20112262482017 @default.
• W2011226248 countsByYear W20112262482018 @default.
• W2011226248 countsByYear W20112262482019 @default.
• W2011226248 countsByYear W20112262482020 @default.
• W2011226248 countsByYear W20112262482021 @default.
• W2011226248 countsByYear W20112262482022 @default.
• W2011226248 countsByYear W20112262482023 @default.
• W2011226248 crossrefType "journal-article" @default.
• W2011226248 hasAuthorship W2011226248A5000557894 @default.
• W2011226248 hasAuthorship W2011226248A5022288501 @default.
• W2011226248 hasAuthorship W2011226248A5057661348 @default.
• W2011226248 hasAuthorship W2011226248A5079431219 @default.
• W2011226248 hasBestOaLocation W20112262481 @default.
• W2011226248 hasConcept C120665830 @default.
• W2011226248 hasConcept C121332964 @default.
• W2011226248 hasConcept C126322002 @default.
• W2011226248 hasConcept C187212893 @default.
• W2011226248 hasConcept C201903717 @default.
• W2011226248 hasConcept C203014093 @default.
• W2011226248 hasConcept C207103383 @default.
• W2011226248 hasConcept C22070199 @default.
• W2011226248 hasConcept C2780252810 @default.
• W2011226248 hasConcept C2908647359 @default.
• W2011226248 hasConcept C44249647 @default.
• W2011226248 hasConcept C50382708 @default.
• W2011226248 hasConcept C61511704 @default.
• W2011226248 hasConcept C71924100 @default.
• W2011226248 hasConcept C72563966 @default.
• W2011226248 hasConcept C99454951 @default.
• W2011226248 hasConceptScore W2011226248C120665830 @default.
• W2011226248 hasConceptScore W2011226248C121332964 @default.
• W2011226248 hasConceptScore W2011226248C126322002 @default.
• W2011226248 hasConceptScore W2011226248C187212893 @default.
• W2011226248 hasConceptScore W2011226248C201903717 @default.
• W2011226248 hasConceptScore W2011226248C203014093 @default.
• W2011226248 hasConceptScore W2011226248C207103383 @default.
• W2011226248 hasConceptScore W2011226248C22070199 @default.
• W2011226248 hasConceptScore W2011226248C2780252810 @default.
• W2011226248 hasConceptScore W2011226248C2908647359 @default.
• W2011226248 hasConceptScore W2011226248C44249647 @default.
• W2011226248 hasConceptScore W2011226248C50382708 @default.
• W2011226248 hasConceptScore W2011226248C61511704 @default.
• W2011226248 hasConceptScore W2011226248C71924100 @default.
• W2011226248 hasConceptScore W2011226248C72563966 @default.
• W2011226248 hasConceptScore W2011226248C99454951 @default.
• W2011226248 hasIssue "4" @default.
• W2011226248 hasLocation W20112262481 @default.
• W2011226248 hasLocation W20112262482 @default.
• W2011226248 hasLocation W20112262483 @default.
• W2011226248 hasLocation W20112262484 @default.
• W2011226248 hasLocation W20112262485 @default.
• W2011226248 hasLocation W20112262486 @default.
• W2011226248 hasLocation W20112262487 @default.
• W2011226248 hasLocation W20112262488 @default.
• W2011226248 hasOpenAccess W2011226248 @default.
• W2011226248 hasPrimaryLocation W20112262481 @default.
• W2011226248 hasRelatedWork W2042380991 @default.
• W2011226248 hasRelatedWork W2044058499 @default.
• W2011226248 hasRelatedWork W2158701418 @default.
• W2011226248 hasRelatedWork W2317811330 @default.
• W2011226248 hasRelatedWork W2409957712 @default.
• W2011226248 hasRelatedWork W2521415133 @default.
• W2011226248 hasRelatedWork W2528919078 @default.

• next