FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011230104> ?p ?o ?g. }

• W2011230104 endingPage "9108" @default.
• W2011230104 startingPage "9103" @default.
• W2011230104 abstract "Transcription factor II D (TFIID) is a multiprotein complex that nucleates formation of the basal transcription machinery. TATA binding protein-associated factors 1 and 7 (TAF1 and TAF7), two subunits of TFIID, are integral to the regulation of eukaryotic transcription initiation and play key roles in preinitiation complex (PIC) assembly. Current models suggest that TAF7 acts as a dissociable inhibitor of TAF1 histone acetyltransferase activity and that this event ensures appropriate assembly of the RNA polymerase II-mediated PIC before transcriptional initiation. Here, we report the 3D structure of a complex of yeast TAF1 with TAF7 at 2.9 Å resolution. The structure displays novel architecture and is characterized by a large predominantly hydrophobic heterodimer interface and extensive cofolding of TAF subunits. There are no obvious similarities between TAF1 and known histone acetyltransferases. Instead, the surface of the TAF1-TAF7 complex contains two prominent conserved surface pockets, one of which binds selectively to an inhibitory trimethylated histone H3 mark on Lys27 in a manner that is also regulated by phosphorylation at the neighboring H3 serine. Our findings could point toward novel roles for the TAF1-TAF7 complex in regulation of PIC assembly via reading epigenetic histone marks." @default.
• W2011230104 created "2016-06-24" @default.
• W2011230104 creator A5007949259 @default.
• W2011230104 creator A5008278245 @default.
• W2011230104 creator A5022264314 @default.
• W2011230104 creator A5031784533 @default.
• W2011230104 creator A5033986223 @default.
• W2011230104 creator A5068245442 @default.
• W2011230104 creator A5085801141 @default.
• W2011230104 creator A5088855738 @default.
• W2011230104 creator A5089812226 @default.
• W2011230104 date "2014-06-10" @default.
• W2011230104 modified "2023-10-10" @default.
• W2011230104 title "Structural and functional insight into TAF1–TAF7, a subcomplex of transcription factor II D" @default.
• W2011230104 cites W1509357297 @default.
• W2011230104 cites W1539796472 @default.
• W2011230104 cites W1967046460 @default.
• W2011230104 cites W1968931043 @default.
• W2011230104 cites W1971096996 @default.
• W2011230104 cites W1971650764 @default.
• W2011230104 cites W1984015499 @default.
• W2011230104 cites W1986191025 @default.
• W2011230104 cites W1992372241 @default.
• W2011230104 cites W1996224069 @default.
• W2011230104 cites W1998867125 @default.
• W2011230104 cites W2005781563 @default.
• W2011230104 cites W2006098987 @default.
• W2011230104 cites W2007387233 @default.
• W2011230104 cites W2009283906 @default.
• W2011230104 cites W2017840637 @default.
• W2011230104 cites W2018875477 @default.
• W2011230104 cites W2022058405 @default.
• W2011230104 cites W2023654260 @default.
• W2011230104 cites W2035503835 @default.
• W2011230104 cites W2046149964 @default.
• W2011230104 cites W2062015108 @default.
• W2011230104 cites W2066271605 @default.
• W2011230104 cites W2076990986 @default.
• W2011230104 cites W2085299836 @default.
• W2011230104 cites W2085515309 @default.
• W2011230104 cites W2086778920 @default.
• W2011230104 cites W2092368988 @default.
• W2011230104 cites W2104130324 @default.
• W2011230104 cites W2116453847 @default.
• W2011230104 cites W2123383914 @default.
• W2011230104 cites W2132629607 @default.
• W2011230104 cites W2144081223 @default.
• W2011230104 cites W2146641795 @default.
• W2011230104 cites W2149223106 @default.
• W2011230104 cites W2180229411 @default.
• W2011230104 doi "https://doi.org/10.1073/pnas.1408293111" @default.
• W2011230104 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4078864" @default.
• W2011230104 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24927529" @default.
• W2011230104 hasPublicationYear "2014" @default.
• W2011230104 type Work @default.
• W2011230104 sameAs 2011230104 @default.
• W2011230104 citedByCount "37" @default.
• W2011230104 countsByYear W20112301042014 @default.
• W2011230104 countsByYear W20112301042015 @default.
• W2011230104 countsByYear W20112301042016 @default.
• W2011230104 countsByYear W20112301042017 @default.
• W2011230104 countsByYear W20112301042018 @default.
• W2011230104 countsByYear W20112301042019 @default.
• W2011230104 countsByYear W20112301042020 @default.
• W2011230104 countsByYear W20112301042021 @default.
• W2011230104 countsByYear W20112301042022 @default.
• W2011230104 countsByYear W20112301042023 @default.
• W2011230104 crossrefType "journal-article" @default.
• W2011230104 hasAuthorship W2011230104A5007949259 @default.
• W2011230104 hasAuthorship W2011230104A5008278245 @default.
• W2011230104 hasAuthorship W2011230104A5022264314 @default.
• W2011230104 hasAuthorship W2011230104A5031784533 @default.
• W2011230104 hasAuthorship W2011230104A5033986223 @default.
• W2011230104 hasAuthorship W2011230104A5068245442 @default.
• W2011230104 hasAuthorship W2011230104A5085801141 @default.
• W2011230104 hasAuthorship W2011230104A5088855738 @default.
• W2011230104 hasAuthorship W2011230104A5089812226 @default.
• W2011230104 hasBestOaLocation W20112301041 @default.
• W2011230104 hasConcept C100733574 @default.
• W2011230104 hasConcept C101762097 @default.
• W2011230104 hasConcept C102622118 @default.
• W2011230104 hasConcept C104317684 @default.
• W2011230104 hasConcept C144825837 @default.
• W2011230104 hasConcept C150194340 @default.
• W2011230104 hasConcept C154816499 @default.
• W2011230104 hasConcept C156951783 @default.
• W2011230104 hasConcept C172768829 @default.
• W2011230104 hasConcept C188740287 @default.
• W2011230104 hasConcept C27153228 @default.
• W2011230104 hasConcept C2776449523 @default.
• W2011230104 hasConcept C44498088 @default.
• W2011230104 hasConcept C54355233 @default.
• W2011230104 hasConcept C64350747 @default.
• W2011230104 hasConcept C67705224 @default.
• W2011230104 hasConcept C86339819 @default.
• W2011230104 hasConcept C86803240 @default.
• W2011230104 hasConcept C95444343 @default.
• W2011230104 hasConceptScore W2011230104C100733574 @default.

• next