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- W2011231198 abstract "Abstract: To identify a possible acute phase response during the steady state of sickle cell disease, we estimated the serum alterations of acute phase proteins, β2-microglobulin (β2M), κ and λ light chains, interleukins (ILs) and tumor necrosis factor-α (TNFα) in 21 patients. Increased concentrations of C-reactive protein (CRP) were found in 5 patients, alpha-1-acid-glycoprotein (AGP) in 3, alpha-1-antitrypsin (AAT) in 8, ceruloplasmin (CER) in 2, alpha-2-macrogiobulin (AMG) in 14 and decreased haptoglobin (HPT) and transferrin (TFR) in 11 and 9, respectively. Increased β2M was found in 10 patients and κ and λ light chains in 11. IL-1β, IL-2, IL-4, IL-10 and TNFα were not detected in any of the patients. However, significantly increased values of IL-6 and sIL-2r were found. This study has demonstrated increased serum levels of some of the acute phase proteins in patients during the steady state of sickle cell disease. This may be a result of a subclinical vaso-occlusion which in turn leads to a covert inflammatory response. Cytokines, and in particular IL-6, produced after this response, seem to be responsible for the high levels of acute phase proteins in the steady state of this disease." @default.
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- W2011231198 date "2009-04-24" @default.
- W2011231198 modified "2023-09-26" @default.
- W2011231198 title "Acute phase proteins and interleukins in steady state sickle cell disease" @default.
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- W2011231198 doi "https://doi.org/10.1111/j.1600-0609.1998.tb01060.x" @default.
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