FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011237427> ?p ?o ?g. }

• W2011237427 abstract "Botulinum neurotoxins are the most potent protein neurotoxin known to human. The dual roles of BoNTs as both the causative agent of human botulism and a widely used protein-based therapeutic agent for treatment of numerous neuromuscular disorders/cosmetic uses make it an extremely hot topic of research. Biochemical characterization of these toxins was mainly confined to the recombinant light chains and substrate and little is known about their efficiency on the cleavage of endogenous substrates. In the present study, we showed that BoNTs exhibited variable activities on their endogenous substrates and that their efficiency to cleave recombinant and endogenous substrate was not consistent, presumably due to the differential recognition of their respective substrates in the natural SNARE complex format. Through testing the combinatorial effects of different BoNTs on cleavage of endogenous substrates, we showed that the combinations of LC/A and LC/B, as well as LC/A and LC/F, could enhance the activity of each individual BoNT. This finding may shed light on the future development of new BoNT serotypes for clinical application, and formulation of combinatorial uses of different BoNTs to minimize the development of immuno-resistance by using a lower amount of individual type." @default.
• W2011237427 created "2016-06-24" @default.
• W2011237427 creator A5001026420 @default.
• W2011237427 creator A5014344571 @default.
• W2011237427 creator A5059057094 @default.
• W2011237427 creator A5079815413 @default.
• W2011237427 date "2015-06-01" @default.
• W2011237427 modified "2023-09-23" @default.
• W2011237427 title "Exploration of endogenous substrate cleavage by various forms of botulinum neurotoxins" @default.
• W2011237427 cites W1918147071 @default.
• W2011237427 cites W1980413801 @default.
• W2011237427 cites W1981764249 @default.
• W2011237427 cites W1984290620 @default.
• W2011237427 cites W1984362334 @default.
• W2011237427 cites W1999427844 @default.
• W2011237427 cites W2001586601 @default.
• W2011237427 cites W2001707924 @default.
• W2011237427 cites W2002034161 @default.
• W2011237427 cites W2006372370 @default.
• W2011237427 cites W2006884809 @default.
• W2011237427 cites W2016959579 @default.
• W2011237427 cites W2019091403 @default.
• W2011237427 cites W2033646733 @default.
• W2011237427 cites W2034704564 @default.
• W2011237427 cites W2037455921 @default.
• W2011237427 cites W2041813390 @default.
• W2011237427 cites W2045996635 @default.
• W2011237427 cites W2052682794 @default.
• W2011237427 cites W2063341449 @default.
• W2011237427 cites W2075449190 @default.
• W2011237427 cites W2078084895 @default.
• W2011237427 cites W2083213048 @default.
• W2011237427 cites W2089927506 @default.
• W2011237427 cites W2093235237 @default.
• W2011237427 cites W2096738649 @default.
• W2011237427 cites W2111510216 @default.
• W2011237427 cites W2126213235 @default.
• W2011237427 cites W2130361661 @default.
• W2011237427 cites W2139853805 @default.
• W2011237427 cites W2471749400 @default.
• W2011237427 doi "https://doi.org/10.1016/j.toxicon.2015.04.008" @default.
• W2011237427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25912942" @default.
• W2011237427 hasPublicationYear "2015" @default.
• W2011237427 type Work @default.
• W2011237427 sameAs 2011237427 @default.
• W2011237427 citedByCount "0" @default.
• W2011237427 crossrefType "journal-article" @default.
• W2011237427 hasAuthorship W2011237427A5001026420 @default.
• W2011237427 hasAuthorship W2011237427A5014344571 @default.
• W2011237427 hasAuthorship W2011237427A5059057094 @default.
• W2011237427 hasAuthorship W2011237427A5079815413 @default.
• W2011237427 hasConcept C104317684 @default.
• W2011237427 hasConcept C151730666 @default.
• W2011237427 hasConcept C159654299 @default.
• W2011237427 hasConcept C16613235 @default.
• W2011237427 hasConcept C175156509 @default.
• W2011237427 hasConcept C181199279 @default.
• W2011237427 hasConcept C185592680 @default.
• W2011237427 hasConcept C19014433 @default.
• W2011237427 hasConcept C2777010668 @default.
• W2011237427 hasConcept C2777367657 @default.
• W2011237427 hasConcept C2779186577 @default.
• W2011237427 hasConcept C2780358027 @default.
• W2011237427 hasConcept C2994342964 @default.
• W2011237427 hasConcept C36394416 @default.
• W2011237427 hasConcept C40767141 @default.
• W2011237427 hasConcept C43369102 @default.
• W2011237427 hasConcept C54355233 @default.
• W2011237427 hasConcept C55493867 @default.
• W2011237427 hasConcept C86803240 @default.
• W2011237427 hasConcept C89423630 @default.
• W2011237427 hasConceptScore W2011237427C104317684 @default.
• W2011237427 hasConceptScore W2011237427C151730666 @default.
• W2011237427 hasConceptScore W2011237427C159654299 @default.
• W2011237427 hasConceptScore W2011237427C16613235 @default.
• W2011237427 hasConceptScore W2011237427C175156509 @default.
• W2011237427 hasConceptScore W2011237427C181199279 @default.
• W2011237427 hasConceptScore W2011237427C185592680 @default.
• W2011237427 hasConceptScore W2011237427C19014433 @default.
• W2011237427 hasConceptScore W2011237427C2777010668 @default.
• W2011237427 hasConceptScore W2011237427C2777367657 @default.
• W2011237427 hasConceptScore W2011237427C2779186577 @default.
• W2011237427 hasConceptScore W2011237427C2780358027 @default.
• W2011237427 hasConceptScore W2011237427C2994342964 @default.
• W2011237427 hasConceptScore W2011237427C36394416 @default.
• W2011237427 hasConceptScore W2011237427C40767141 @default.
• W2011237427 hasConceptScore W2011237427C43369102 @default.
• W2011237427 hasConceptScore W2011237427C54355233 @default.
• W2011237427 hasConceptScore W2011237427C55493867 @default.
• W2011237427 hasConceptScore W2011237427C86803240 @default.
• W2011237427 hasConceptScore W2011237427C89423630 @default.
• W2011237427 hasLocation W20112374271 @default.
• W2011237427 hasLocation W20112374272 @default.
• W2011237427 hasOpenAccess W2011237427 @default.
• W2011237427 hasPrimaryLocation W20112374271 @default.
• W2011237427 hasRelatedWork W1546903323 @default.
• W2011237427 hasRelatedWork W1776550187 @default.
• W2011237427 hasRelatedWork W1999427844 @default.
• W2011237427 hasRelatedWork W2013531154 @default.
• W2011237427 hasRelatedWork W2071902871 @default.

• next