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- W2011248852 abstract "SummaryThe basic pharmacokinetics of theophylline are reviewed and the various factors, such as smoking, diet, age and sex, which influence its metabolism are briefly discussed. Studies have been carried out in normal volunteers to investigate the effect of formulation on theophylline bioavailability. The results showed the bioequivalence of a rapidly-dissoluting tablet formulation QTheolair-125′) with theophylline elixir, confirming the complete absorption of theophylline from a solid oral dosage form. Administered at a dosage of 250 mg 3-times a day for 7 days, both formulations provided plasma theophylline concentrations within the accepted therapeutic range. The pharmacokinetics of a single 500 mg dose of a new sustained-release theophylline preparation (‘Theolair SR”) were also compared with those of another sustained-release preparation and the rapidly-dissoluting tablet formulation. The data indicated that, although plasma theophylline concentrations increased at a slower rate with the sustained-release formulations, absorption was essentially complete with all three preparations. Preliminary results of a multiple dose study with ‘Theolair SR’ indicate that therapeutic blood concentrations of theophylline can be maintained adequately with a twice-daily regimen." @default.
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- W2011248852 date "1979-01-01" @default.
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- W2011248852 title "The pharmacokinetics of theophylline" @default.
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- W2011248852 doi "https://doi.org/10.1185/03007997909115902" @default.
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