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• W2011250388 abstract "The metabolism of glucose to glycogen in the liver of fasted and well-fed rats was investigated with13C nuclear magnetic resonance spectroscopy using [1,2-13C2]glucose as the main substrate. The unique spectroscopic feature of this molecule is the13C-13C homonuclear coupling leading to characteristic dublets for the C-1 and C-2 resonances of glucose and its breakdown products as long as the two13C nuclei remain bonded together. The doublet resonances of [1,2-13C2]glucose thus provide an ideal marker to follow the fate of this exogenous substrate through the metabolic pathways. [1,2-13C2]Glucose was injected intraperitoneally into anesthetized rats and the in vivo13C-NMR measurements of the intact animals revealed the transformation of the injected glucose into liver glycogen. Glycogen was extracted from the liver and high resolution13C-NMR spectra were obtained before and after hydrolysis of glycogen. Intact [1,2-13C2]glucose molecules give rise to doublet resonances, natural abundance [13C]glucose molecules produce singlet resonances. From an analysis of the doublet-to-singlet intensities the following conclusions were derived. (i) In fasted rats virtually 100% of the glycosyl units in glycogen were13C-NMR visible. In contrast, the13C-NMR visibility of glycogen decreased to 30–40% in well-fed rats. (ii) In fed rats a minimum of 67 ± 7% of the exogenous [1,2-13C2]glucose was incorporated into the liver glycogen via the direct pathway. No contribution of the indirect pathway could be detected. (iii) In fasted rats externally supplied glucose appeared to be consumed in different metabolic processes and less [1,2-13C2]glucose was found to be incorporated into glycogen (13 ± 1%). However, the observation of [5,6-13C2]glucose in liver glycogen provided evicence for the operation of the so-called indirect pathway of glycogen synthesis. The activity of the indirect pathway was at least 9% but not more than 30% of the direct pathway. (vi) The pentose phosphate pathway was of little significance for glucose but became detectable upon injection of [1-13C]ribose." @default.
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• W2011250388 date "1991-10-01" @default.
• W2011250388 modified "2023-10-13" @default.
• W2011250388 title "Glycogen metabolism as detected by in vivo and in vitro13C-NMR spectroscopy using [1,2-13C2]glucose as substrate" @default.
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• W2011250388 doi "https://doi.org/10.1016/0167-4889(91)90071-5" @default.
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