FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011258416> ?p ?o ?g. }

• W2011258416 endingPage "463" @default.
• W2011258416 startingPage "450" @default.
• W2011258416 abstract "We hypothesize that maternal metallothionein (MT) induction by toxic dosages of chemicals may contribute to or cause developmental toxicity by a chain of events leading to a transient but developmentally adverse decrease in Zn availability to the embryo. This hypothesis was tested by evaluating hepatic MT induction, maternal and embryonic Zn status, and developmental toxicity after exposure to urethane, a developmental toxicant, or styrene, which is not a developmental toxicant. Pregnant Sprague-Dawley rats were given 0 or 1 g/kg urethane ip, or 0 or 300 mg/kg styrene in corn oil po, on Gestation Day 11 (sperm positive = Gestation Day 0). These were maternally toxic dosages. As both treatments decreased food consumption, separate pair-fed control groups were also evaluated for effects on MT and Zn status and development. In addition, Gestation Day 11 rat embryos were exposed to urethane in vitro in order to determine whether urethane has the potential to be directly embryotoxic. Urethane treatment induced hepatic MT 14-fold over control; styrene treatment induced MT 2.5-fold. The MT induction by styrene could be attributed to decreased food intake, as a similar level of induction was observed in a pair-fed untreated control group. However, the level of MT induction by urethane was much greater than that produced by decreased food intake alone. Hepatic Zn concentration, particularly in the cytosol, was increased in the presence of increased hepatic MT concentration. Plasma Zn concentration was significantly decreased (approximately 30%) by urethane treatment, but not by styrene or food restriction (pair-feeding). Distribution of 65Zn to the liver of urethane-treated dams was significantly greater (by 30%), while distribution to embryonic tissues was significantly lower (by at least 50%) than in pair-fed or ad lib.-fed controls. Styrene treatment had no effect on 65Zn distribution. Urethane was developmentally toxic, causing an 18% decrease in fetal weight and a significant delay in skeletal ossification, but was not toxic to rat embryos in vitro. Styrene was not developmentally toxic. The changes observed after urethane treatment, namely substantial hepatic MT induction and altered maternal and embryonic Zn status, along with the lack of direct embryotoxicity of urethane in vitro, support the hypothesis that these maternal effects contribute to developmental toxicity. The lack of similar changes in styrene-intoxicated dams provides one explanation for its low developmental toxicity at maternally toxic dosages." @default.
• W2011258416 created "2016-06-24" @default.
• W2011258416 creator A5025291709 @default.
• W2011258416 creator A5028725177 @default.
• W2011258416 creator A5029178085 @default.
• W2011258416 creator A5029319985 @default.
• W2011258416 creator A5043985150 @default.
• W2011258416 creator A5083702469 @default.
• W2011258416 date "1991-09-01" @default.
• W2011258416 modified "2023-09-27" @default.
• W2011258416 title "The role of metallothionein induction and altered zinc status in maternally mediated developmental toxicity: Comparison of the effects of urethane and styrene in rats" @default.
• W2011258416 cites W1543669829 @default.
• W2011258416 cites W1775749144 @default.
• W2011258416 cites W1839823486 @default.
• W2011258416 cites W1971141682 @default.
• W2011258416 cites W1972162864 @default.
• W2011258416 cites W1976215546 @default.
• W2011258416 cites W1976588543 @default.
• W2011258416 cites W1977228369 @default.
• W2011258416 cites W1985515035 @default.
• W2011258416 cites W1987213613 @default.
• W2011258416 cites W1989490310 @default.
• W2011258416 cites W2008072001 @default.
• W2011258416 cites W2021392024 @default.
• W2011258416 cites W2021555474 @default.
• W2011258416 cites W2026192439 @default.
• W2011258416 cites W2040208650 @default.
• W2011258416 cites W2040709751 @default.
• W2011258416 cites W2051513396 @default.
• W2011258416 cites W2068066654 @default.
• W2011258416 cites W2068743220 @default.
• W2011258416 cites W2069392419 @default.
• W2011258416 cites W2088210995 @default.
• W2011258416 cites W2102246612 @default.
• W2011258416 cites W2103199749 @default.
• W2011258416 cites W2122877713 @default.
• W2011258416 cites W2137326836 @default.
• W2011258416 cites W2144402626 @default.
• W2011258416 cites W2159220491 @default.
• W2011258416 cites W2197227471 @default.
• W2011258416 cites W2318340336 @default.
• W2011258416 cites W2332148883 @default.
• W2011258416 doi "https://doi.org/10.1016/0041-008x(91)90046-h" @default.
• W2011258416 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1949013" @default.
• W2011258416 hasPublicationYear "1991" @default.
• W2011258416 type Work @default.
• W2011258416 sameAs 2011258416 @default.
• W2011258416 citedByCount "50" @default.
• W2011258416 countsByYear W20112584162012 @default.
• W2011258416 countsByYear W20112584162017 @default.
• W2011258416 countsByYear W20112584162018 @default.
• W2011258416 countsByYear W20112584162019 @default.
• W2011258416 countsByYear W20112584162022 @default.
• W2011258416 crossrefType "journal-article" @default.
• W2011258416 hasAuthorship W2011258416A5025291709 @default.
• W2011258416 hasAuthorship W2011258416A5028725177 @default.
• W2011258416 hasAuthorship W2011258416A5029178085 @default.
• W2011258416 hasAuthorship W2011258416A5029319985 @default.
• W2011258416 hasAuthorship W2011258416A5043985150 @default.
• W2011258416 hasAuthorship W2011258416A5083702469 @default.
• W2011258416 hasConcept C104317684 @default.
• W2011258416 hasConcept C126322002 @default.
• W2011258416 hasConcept C134018914 @default.
• W2011258416 hasConcept C15920480 @default.
• W2011258416 hasConcept C162156334 @default.
• W2011258416 hasConcept C178790620 @default.
• W2011258416 hasConcept C179335377 @default.
• W2011258416 hasConcept C185592680 @default.
• W2011258416 hasConcept C195289149 @default.
• W2011258416 hasConcept C196843134 @default.
• W2011258416 hasConcept C20719415 @default.
• W2011258416 hasConcept C2777566558 @default.
• W2011258416 hasConcept C2778206080 @default.
• W2011258416 hasConcept C2779234561 @default.
• W2011258416 hasConcept C2780473477 @default.
• W2011258416 hasConcept C29730261 @default.
• W2011258416 hasConcept C33070731 @default.
• W2011258416 hasConcept C46973012 @default.
• W2011258416 hasConcept C521977710 @default.
• W2011258416 hasConcept C54355233 @default.
• W2011258416 hasConcept C55493867 @default.
• W2011258416 hasConcept C65290608 @default.
• W2011258416 hasConcept C71924100 @default.
• W2011258416 hasConcept C86803240 @default.
• W2011258416 hasConcept C95444343 @default.
• W2011258416 hasConcept C98274493 @default.
• W2011258416 hasConcept C99432707 @default.
• W2011258416 hasConceptScore W2011258416C104317684 @default.
• W2011258416 hasConceptScore W2011258416C126322002 @default.
• W2011258416 hasConceptScore W2011258416C134018914 @default.
• W2011258416 hasConceptScore W2011258416C15920480 @default.
• W2011258416 hasConceptScore W2011258416C162156334 @default.
• W2011258416 hasConceptScore W2011258416C178790620 @default.
• W2011258416 hasConceptScore W2011258416C179335377 @default.
• W2011258416 hasConceptScore W2011258416C185592680 @default.
• W2011258416 hasConceptScore W2011258416C195289149 @default.
• W2011258416 hasConceptScore W2011258416C196843134 @default.
• W2011258416 hasConceptScore W2011258416C20719415 @default.

• next