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• W2011266163 abstract "Abstract Three distinct subsets of antigen‐experienced CD8 + T cells have been identified so far: short‐living effector T cells (T EC ) and two long‐living subsets, described as central (T CM ) and effector memory (T EM ) T cells. The lineage relationships of these subpopulations as well as their involvement in protection have not yet been conclusively determined. We recently described a novel marker combination (CD127 and CD62L) to identify all three major CD8 + T cell subsets in mice infected with Listeria monocytogenes (L.m.) . Extensive lineage relationship analyses on highly purified subpopulations after in vitro and in vivo stimulation demonstrated that T CM can develop into T EM or T EC , whereas T EM can only progress to T EC cells. Short‐living T EC never regained a T EM or T CM phenotype. These data strongly suggest a hierarchical and unidirectional order of developmental stages. In vivo priming protocols that preferentially induced one of the different CD8 + T cell subsets demonstrated that predominance of T EM (CD40 stimulation) correlated best with effective protection against L.m. , whereas generation of neither T CM (by immunization with heat‐killed L.m. ) nor T EC (by systemic co‐administration of CpG during primary infection) conferred substantial long‐term protective immunity. These findings have important implications for the design of more effective T cell‐based vaccines." @default.
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• W2011266163 date "2006-05-24" @default.
• W2011266163 modified "2023-10-15" @default.
• W2011266163 title "Unidirectional development of CD8+ central memory T cells into protectiveListeria-specific effector memory T cells" @default.
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• W2011266163 doi "https://doi.org/10.1002/eji.200635874" @default.
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