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- W2011271036 abstract "OBJECTIVE: Growing evidence indicates that menopausal onset is remarkably not advanced in women having undergone unilateral oophorectomy early in life, suggesting that compensating mechanisms are at play in initial follicle recruitment. As AMH probably is also implicated in this latter process, and its serum levels reflect the number of growing and non-growing follicles, we decided to investigate whether per-follicle AMH production is altered in unilaterally oophorectomized patients. DESIGN: Prospective study. MATERIALS AND METHODS: 230 infertile, non-PCOS, non-endometriosis women, 20-43 years of age, having a single remaining ovary as a result of unilateral oophorectomy (One Ovary group; n= 30) or two ovaries (Control group) (n=200) were studied. In both groups, serum AMH and number and size of antral follicles (3-12 mm) were measured on cycle day 3. In an effort to assess per-follicle AMH production, we calculated the ratio serum AMH levels/antral follicle count (AFC) and the strength of the correlation between both parameters. RESULTS: Whereas median AMH levels and AFC were markedly lower in the One Ovary group than in the Control group (1.1 (0.21-3.56) vs. 2.22 (0.04-6.19) ng/mL, P<0.001; 7 (1-14) vs. 13 (2-24) follicles, P<0.001), respectively, per-follicle AMH levels remained similar in both groups (0.19 ± 0.1 vs. 0.18 ± 0.02 ng/mL/follicle, respectively). In addition, correlation between AMH and AFC was unaffected in patients the One ovary group (r=0.77; P <0.001) as compared to the Control group (r=0.67; P<0.001). CONCLUSION: That both the strength of the correlation between serum AMH levels and AFC and the ratio between the two parameters remained comparable in the One Ovary and Control groups is not consistent with the presumable implication of AMH in the mechanisms that drive follicle loss in unilaterally oophorectomized patients." @default.
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- W2011271036 date "2010-09-01" @default.
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- W2011271036 title "Unilateral oophorectomy fails to alter anti-mÜllerian hormone/antral follicle count ratio, suggesting unchanged per-follicle AMH production in the remaining ovary" @default.
- W2011271036 doi "https://doi.org/10.1016/j.fertnstert.2010.07.711" @default.
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