FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011277680> ?p ?o ?g. }

• W2011277680 endingPage "273" @default.
• W2011277680 startingPage "264" @default.
• W2011277680 abstract "Cell adhesion molecules mediate leukocyte recruitment into the irradiated organs; modulation of this process may protect from radiation damage. Our objective was to characterize the requirement for intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) in intestinal inflammatory response after abdominal irradiation.Endothelial ICAM-1 and VCAM-1 expression was determined using radiolabeled antibodies in mice 24 h and 14 days after irradiation with 10 Gy, or sham radiation. Leukocyte-endothelial cell interactions in intestinal venules were assessed using intravital microscopy, and the function of ICAM-1 and VCAM-1 in this process by using blocking antibodies and ICAM-1(-/-) mice.The number of adherent leukocytes significantly increased 24 h after irradiation and remained elevated at 14 days. Treatment with anti-ICAM-1 antibodies and ICAM-1 genetic deficiency significantly reduced leukocyte adhesion 24 h after irradiation. At 14 days after irradiation, both wild-type and ICAM-1(-/-) mice had an upregulation of VCAM-1, expression, and VCAM-1 immunoneutralization, but not ICAM-1 immunoneutralization, significantly reduced leukocyte adhesion. In ICAM-1(-/-) mice, regeneration of the intestinal epithelium was enhanced relative to wild-type mice.ICAM-1 plays a key role in leukocyte recruitment at early time points after abdominal irradiation, whereas VCAM-1 is the main molecular determinant of leukocyte recruitment at late time points." @default.
• W2011277680 created "2016-06-24" @default.
• W2011277680 creator A5004953927 @default.
• W2011277680 creator A5017174323 @default.
• W2011277680 creator A5023065458 @default.
• W2011277680 creator A5025082765 @default.
• W2011277680 creator A5040354010 @default.
• W2011277680 creator A5049524652 @default.
• W2011277680 creator A5067673746 @default.
• W2011277680 creator A5073496723 @default.
• W2011277680 date "2003-09-01" @default.
• W2011277680 modified "2023-10-08" @default.
• W2011277680 title "Relative roles of ICAM-1 and VCAM-1 in the pathogenesis of experimental radiation-induced intestinal inflammation" @default.
• W2011277680 cites W1487121574 @default.
• W2011277680 cites W1513845930 @default.
• W2011277680 cites W1545258668 @default.
• W2011277680 cites W1838328739 @default.
• W2011277680 cites W1856960941 @default.
• W2011277680 cites W1875918201 @default.
• W2011277680 cites W1970017365 @default.
• W2011277680 cites W1974333680 @default.
• W2011277680 cites W1982923730 @default.
• W2011277680 cites W2001000725 @default.
• W2011277680 cites W2008771785 @default.
• W2011277680 cites W2009174735 @default.
• W2011277680 cites W2022479433 @default.
• W2011277680 cites W2027170943 @default.
• W2011277680 cites W2039330179 @default.
• W2011277680 cites W2044351980 @default.
• W2011277680 cites W2067501865 @default.
• W2011277680 cites W2072251818 @default.
• W2011277680 cites W2074246451 @default.
• W2011277680 cites W2080580789 @default.
• W2011277680 cites W2080745321 @default.
• W2011277680 cites W2099318652 @default.
• W2011277680 cites W2101399229 @default.
• W2011277680 cites W2107393704 @default.
• W2011277680 cites W2134138329 @default.
• W2011277680 cites W2149277015 @default.
• W2011277680 cites W2150903941 @default.
• W2011277680 cites W2186673641 @default.
• W2011277680 cites W2282977891 @default.
• W2011277680 cites W2426390122 @default.
• W2011277680 doi "https://doi.org/10.1016/s0360-3016(03)00523-6" @default.
• W2011277680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12909242" @default.
• W2011277680 hasPublicationYear "2003" @default.
• W2011277680 type Work @default.
• W2011277680 sameAs 2011277680 @default.
• W2011277680 citedByCount "79" @default.
• W2011277680 countsByYear W20112776802012 @default.
• W2011277680 countsByYear W20112776802013 @default.
• W2011277680 countsByYear W20112776802014 @default.
• W2011277680 countsByYear W20112776802015 @default.
• W2011277680 countsByYear W20112776802016 @default.
• W2011277680 countsByYear W20112776802017 @default.
• W2011277680 countsByYear W20112776802018 @default.
• W2011277680 countsByYear W20112776802019 @default.
• W2011277680 countsByYear W20112776802020 @default.
• W2011277680 countsByYear W20112776802021 @default.
• W2011277680 countsByYear W20112776802022 @default.
• W2011277680 countsByYear W20112776802023 @default.
• W2011277680 crossrefType "journal-article" @default.
• W2011277680 hasAuthorship W2011277680A5004953927 @default.
• W2011277680 hasAuthorship W2011277680A5017174323 @default.
• W2011277680 hasAuthorship W2011277680A5023065458 @default.
• W2011277680 hasAuthorship W2011277680A5025082765 @default.
• W2011277680 hasAuthorship W2011277680A5040354010 @default.
• W2011277680 hasAuthorship W2011277680A5049524652 @default.
• W2011277680 hasAuthorship W2011277680A5067673746 @default.
• W2011277680 hasAuthorship W2011277680A5073496723 @default.
• W2011277680 hasConcept C126322002 @default.
• W2011277680 hasConcept C12722491 @default.
• W2011277680 hasConcept C134659918 @default.
• W2011277680 hasConcept C142724271 @default.
• W2011277680 hasConcept C153911025 @default.
• W2011277680 hasConcept C16224149 @default.
• W2011277680 hasConcept C178790620 @default.
• W2011277680 hasConcept C185592680 @default.
• W2011277680 hasConcept C185946421 @default.
• W2011277680 hasConcept C203014093 @default.
• W2011277680 hasConcept C2776914184 @default.
• W2011277680 hasConcept C2776985958 @default.
• W2011277680 hasConcept C2859252 @default.
• W2011277680 hasConcept C2909375385 @default.
• W2011277680 hasConcept C71924100 @default.
• W2011277680 hasConcept C84416704 @default.
• W2011277680 hasConcept C85789140 @default.
• W2011277680 hasConcept C86803240 @default.
• W2011277680 hasConcept C95444343 @default.
• W2011277680 hasConceptScore W2011277680C126322002 @default.
• W2011277680 hasConceptScore W2011277680C12722491 @default.
• W2011277680 hasConceptScore W2011277680C134659918 @default.
• W2011277680 hasConceptScore W2011277680C142724271 @default.
• W2011277680 hasConceptScore W2011277680C153911025 @default.
• W2011277680 hasConceptScore W2011277680C16224149 @default.
• W2011277680 hasConceptScore W2011277680C178790620 @default.
• W2011277680 hasConceptScore W2011277680C185592680 @default.
• W2011277680 hasConceptScore W2011277680C185946421 @default.

• next