Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011281884> ?p ?o ?g. }
Showing items 1 to 84 of
84
with 100 items per page.
- W2011281884 endingPage "85" @default.
- W2011281884 startingPage "82" @default.
- W2011281884 abstract "The involvement of nitric oxide (NO) in ischemia-reperfusion injury remains controversial and has been reported to be both beneficial and deleterious. The purpose of this study was to examine the contribution of NO and superoxide to skeletal muscle function using an ischemic revascularized hind limb model in rats.Warm ischemia produced by vascular pedicle clamping was sustained for 3 h. The animals were divided into four groups according to the solution administrated: (1) saline, (2) N-methyl-L-arginine acetate (L-NMMA), (3) L-NMMA + N-(N-L-g-glutamyl-S-nitroso-l-cysteinyl)glycine (S-nitrosoglutathione), or (4) superoxide dismutase (SOD). Saline, L-NMMA, or L-NMMA + S-nitrosoglutathione was infused for the first 2 h of reperfusion. The SOD was administered as an intravenous bolus 5 min before the onset of reperfusion. Postischemic blood flow was measured by a Doppler flow meter. Muscle contractile function was determined after 24 h of reperfusion.Postischemic blood flow was significantly decreased by the L-NMMA infusion compared with that in the saline-treated group. No significant difference in postischemic blood flow was noted in the saline-, L-NMMA + S-nitrosoglutathione-, and SOD-treated groups. Contractile function of the gastrocnemius muscle in the L-NMMA-and SOD-treated groups, but not in the L-NMMA + S-nitrosoglutathione group, was significantly better than that in the saline-treated group.Limiting postischemic blood flow and SOD infusion are both beneficial in decreasing the ischemia-reperfusion injury of skeletal muscle. S-Nitrosoglutathione infusion following suppression of endogenous NO production does not reduce ischemia-reperfusion injury." @default.
- W2011281884 created "2016-06-24" @default.
- W2011281884 creator A5001941934 @default.
- W2011281884 creator A5014869239 @default.
- W2011281884 creator A5039459970 @default.
- W2011281884 creator A5043264911 @default.
- W2011281884 creator A5064352960 @default.
- W2011281884 creator A5066304083 @default.
- W2011281884 creator A5079712181 @default.
- W2011281884 date "2002-07-01" @default.
- W2011281884 modified "2023-10-16" @default.
- W2011281884 title "Effect of Nitric Oxide on the Contractile Function of Rat Reperfused Skeletal Muscle" @default.
- W2011281884 cites W2024695917 @default.
- W2011281884 cites W2028884768 @default.
- W2011281884 cites W2040852689 @default.
- W2011281884 cites W2055069719 @default.
- W2011281884 cites W2073505957 @default.
- W2011281884 cites W2083978539 @default.
- W2011281884 cites W2987914038 @default.
- W2011281884 doi "https://doi.org/10.1006/jsre.2002.6395" @default.
- W2011281884 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12127812" @default.
- W2011281884 hasPublicationYear "2002" @default.
- W2011281884 type Work @default.
- W2011281884 sameAs 2011281884 @default.
- W2011281884 citedByCount "4" @default.
- W2011281884 countsByYear W20112818842022 @default.
- W2011281884 crossrefType "journal-article" @default.
- W2011281884 hasAuthorship W2011281884A5001941934 @default.
- W2011281884 hasAuthorship W2011281884A5014869239 @default.
- W2011281884 hasAuthorship W2011281884A5039459970 @default.
- W2011281884 hasAuthorship W2011281884A5043264911 @default.
- W2011281884 hasAuthorship W2011281884A5064352960 @default.
- W2011281884 hasAuthorship W2011281884A5066304083 @default.
- W2011281884 hasAuthorship W2011281884A5079712181 @default.
- W2011281884 hasConcept C126322002 @default.
- W2011281884 hasConcept C134018914 @default.
- W2011281884 hasConcept C158846371 @default.
- W2011281884 hasConcept C185592680 @default.
- W2011281884 hasConcept C2775838275 @default.
- W2011281884 hasConcept C2776151105 @default.
- W2011281884 hasConcept C2777397205 @default.
- W2011281884 hasConcept C2779959927 @default.
- W2011281884 hasConcept C2780114680 @default.
- W2011281884 hasConcept C42219234 @default.
- W2011281884 hasConcept C51738704 @default.
- W2011281884 hasConcept C519581460 @default.
- W2011281884 hasConcept C541997718 @default.
- W2011281884 hasConcept C71924100 @default.
- W2011281884 hasConceptScore W2011281884C126322002 @default.
- W2011281884 hasConceptScore W2011281884C134018914 @default.
- W2011281884 hasConceptScore W2011281884C158846371 @default.
- W2011281884 hasConceptScore W2011281884C185592680 @default.
- W2011281884 hasConceptScore W2011281884C2775838275 @default.
- W2011281884 hasConceptScore W2011281884C2776151105 @default.
- W2011281884 hasConceptScore W2011281884C2777397205 @default.
- W2011281884 hasConceptScore W2011281884C2779959927 @default.
- W2011281884 hasConceptScore W2011281884C2780114680 @default.
- W2011281884 hasConceptScore W2011281884C42219234 @default.
- W2011281884 hasConceptScore W2011281884C51738704 @default.
- W2011281884 hasConceptScore W2011281884C519581460 @default.
- W2011281884 hasConceptScore W2011281884C541997718 @default.
- W2011281884 hasConceptScore W2011281884C71924100 @default.
- W2011281884 hasIssue "1" @default.
- W2011281884 hasLocation W20112818841 @default.
- W2011281884 hasLocation W20112818842 @default.
- W2011281884 hasOpenAccess W2011281884 @default.
- W2011281884 hasPrimaryLocation W20112818841 @default.
- W2011281884 hasRelatedWork W2058153407 @default.
- W2011281884 hasRelatedWork W2062533504 @default.
- W2011281884 hasRelatedWork W2082825369 @default.
- W2011281884 hasRelatedWork W2123638924 @default.
- W2011281884 hasRelatedWork W2353492195 @default.
- W2011281884 hasRelatedWork W2357126127 @default.
- W2011281884 hasRelatedWork W2414749468 @default.
- W2011281884 hasRelatedWork W2428157261 @default.
- W2011281884 hasRelatedWork W2512785966 @default.
- W2011281884 hasRelatedWork W2034291382 @default.
- W2011281884 hasVolume "106" @default.
- W2011281884 isParatext "false" @default.
- W2011281884 isRetracted "false" @default.
- W2011281884 magId "2011281884" @default.
- W2011281884 workType "article" @default.