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• W2011283786 abstract "Accumulated knowledge in the molecular processes of tumour development combined with the availability of genetically modified viruses resemble the basis for new promising cancer therapeutics. The main advantages of employing replication-competent viruses are achievement of tumour selective killing and amplification of their oncolytic potential within the tumour mass. In this review, we describe the development of ONYX-015, one of the first and most advanced replication-competent viruses for cancer therapy. We discuss the molecular biology of this therapeutic approach and the interesting results obtained with this virus in clinical trials." @default.
• W2011283786 created "2016-06-24" @default.
• W2011283786 creator A5017147016 @default.
• W2011283786 creator A5040325455 @default.
• W2011283786 date "2002-01-07" @default.
• W2011283786 modified "2023-10-18" @default.
• W2011283786 title "ONYX-015: mechanisms of action and clinical potential of a replication-selective adenovirus" @default.
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• W2011283786 doi "https://doi.org/10.1038/sj.bjc.6600006" @default.
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