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• W2011284393 abstract "Objective: Paraoxonase 1 (PON1) was suggested to lower the risk of coronary artery disease (CAD) by preventing high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) oxidation during atherosclerotic process. The relation between PON1 activity and CAD has been attributed to polymorphisms in the gene coding for this enzyme. The PON1 gene has two common polymorphisms, which lead to a leucine→ methionine substitution at position 55 (PON55) and a glutamine→ arginine substitution at position 192 (PON192), have been defined as the molecular basis of interindividual variability in PON activity. The aim of this study was to investigate the frequency of PON55 and PON192 polymorphisms in Turkish patients with CAD and to determine whether this polymorphism was effective on plasma lipid levels. Material and Methods: One hundred and thirty-five angiographically-defined CAD patients and 110 healthy controls were screened for the PON55 and PON192 genotypes and plasma lipids. Results: The frequency of PON55 MM genotype was significantly higher in the CAD patients than in the controls. The frequencies of PON192 genotypes were similar among CAD patients and controls. Both for PON55 and PON192 genotypes the HDL-C levels of CAD patients were significantly lower than in the corresponding controls. The severity of CAD was not associated with either the PON55 or the PON192 genotype. Conclusion: PON55 and PON192 genotypes are not useful markers for the estimation of either cardiovascular risk or the severity of coronary artery disease in the Turkish population." @default.
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• W2011284393 date "2013-01-01" @default.
• W2011284393 modified "2023-09-26" @default.
• W2011284393 title "Distribution of Pon L/M55 and Q/R192 Genotypes in Turkish Patients with Angiographically-Defined Coronary Artery Disease: Effects on Serum Lipids" @default.
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• W2011284393 doi "https://doi.org/10.5336/medsci.2012-31126" @default.
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