Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011298300> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2011298300 endingPage "43" @default.
- W2011298300 startingPage "35" @default.
- W2011298300 abstract "Various doses of GABA or 0.9% NaCl in a volume of 2 μl were injected into the 3rd ventricle in conscious, free-moving rats and the effect on LH and prolactin release evaluated by measurements of plasma levels by immunoassay. Both in ovariectomized (OVX) and in ovariectomized estrogen-progesterone pretreated (OEP) rats GABA elevated plasma LH at doses of 4 and 8 μM. GABA had opposite effects on plasma prolactin depending on the dose in both types of rats with a suppression of prolactin release obtained with low doses of 0.1 μM in both OVX and OEP rats and of 2 μM in OEP rats and with an elevation in plasma prolactin induced by higher doses of 4 or 8 μM in both types of rats. These effects were mediated centrally since peripheral injection of the 4 μM dose of GABA had no effect on either LH or prolactin. Injection of the GABA blocker, bicuculline at doses of 1 or 2 μM had no consistent significant effect on plasma LH or prolactin in OVX rats. Both doses of bicuculline blocked the stimulatory effect of a 4 μM dose of GABA on LH but the higher dose was required to block the effect of this dose of GABA on prolactin. The results are interpreted to mean that GABA can stimulate release of LHRH from the hypothalamus and that at low doses it can inhibit prolactin release probably by a hypothalamic action. This effect is reversed at high doses to produce stimulation of prolactin release which is also probably mediated by the hypothalamus." @default.
- W2011298300 created "2016-06-24" @default.
- W2011298300 creator A5030124668 @default.
- W2011298300 creator A5069185819 @default.
- W2011298300 date "1978-10-01" @default.
- W2011298300 modified "2023-09-27" @default.
- W2011298300 title "The effects of intraventricular injection of γ-aminobutyric acid (GABA) on prolactin and gonadotropin release in conscious female rats" @default.
- W2011298300 cites W1986075540 @default.
- W2011298300 cites W1987848082 @default.
- W2011298300 cites W1988626400 @default.
- W2011298300 cites W1989901076 @default.
- W2011298300 cites W2021201177 @default.
- W2011298300 cites W2040742860 @default.
- W2011298300 cites W2053905609 @default.
- W2011298300 cites W2078991586 @default.
- W2011298300 cites W2087125721 @default.
- W2011298300 cites W2090797645 @default.
- W2011298300 cites W2090867217 @default.
- W2011298300 cites W2121072841 @default.
- W2011298300 cites W2305627972 @default.
- W2011298300 doi "https://doi.org/10.1016/0006-8993(78)90303-7" @default.
- W2011298300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/688015" @default.
- W2011298300 hasPublicationYear "1978" @default.
- W2011298300 type Work @default.
- W2011298300 sameAs 2011298300 @default.
- W2011298300 citedByCount "146" @default.
- W2011298300 countsByYear W20112983002012 @default.
- W2011298300 countsByYear W20112983002013 @default.
- W2011298300 countsByYear W20112983002020 @default.
- W2011298300 countsByYear W20112983002021 @default.
- W2011298300 crossrefType "journal-article" @default.
- W2011298300 hasAuthorship W2011298300A5030124668 @default.
- W2011298300 hasAuthorship W2011298300A5069185819 @default.
- W2011298300 hasConcept C126322002 @default.
- W2011298300 hasConcept C134018914 @default.
- W2011298300 hasConcept C168258287 @default.
- W2011298300 hasConcept C170493617 @default.
- W2011298300 hasConcept C185592680 @default.
- W2011298300 hasConcept C24998067 @default.
- W2011298300 hasConcept C2777003273 @default.
- W2011298300 hasConcept C2777164284 @default.
- W2011298300 hasConcept C2778782382 @default.
- W2011298300 hasConcept C2779064019 @default.
- W2011298300 hasConcept C2780763569 @default.
- W2011298300 hasConcept C71315377 @default.
- W2011298300 hasConcept C71924100 @default.
- W2011298300 hasConcept C8264082 @default.
- W2011298300 hasConceptScore W2011298300C126322002 @default.
- W2011298300 hasConceptScore W2011298300C134018914 @default.
- W2011298300 hasConceptScore W2011298300C168258287 @default.
- W2011298300 hasConceptScore W2011298300C170493617 @default.
- W2011298300 hasConceptScore W2011298300C185592680 @default.
- W2011298300 hasConceptScore W2011298300C24998067 @default.
- W2011298300 hasConceptScore W2011298300C2777003273 @default.
- W2011298300 hasConceptScore W2011298300C2777164284 @default.
- W2011298300 hasConceptScore W2011298300C2778782382 @default.
- W2011298300 hasConceptScore W2011298300C2779064019 @default.
- W2011298300 hasConceptScore W2011298300C2780763569 @default.
- W2011298300 hasConceptScore W2011298300C71315377 @default.
- W2011298300 hasConceptScore W2011298300C71924100 @default.
- W2011298300 hasConceptScore W2011298300C8264082 @default.
- W2011298300 hasIssue "1" @default.
- W2011298300 hasLocation W20112983001 @default.
- W2011298300 hasLocation W20112983002 @default.
- W2011298300 hasOpenAccess W2011298300 @default.
- W2011298300 hasPrimaryLocation W20112983001 @default.
- W2011298300 hasRelatedWork W1977837856 @default.
- W2011298300 hasRelatedWork W2002384464 @default.
- W2011298300 hasRelatedWork W2006542420 @default.
- W2011298300 hasRelatedWork W2030613578 @default.
- W2011298300 hasRelatedWork W2035021492 @default.
- W2011298300 hasRelatedWork W2052543888 @default.
- W2011298300 hasRelatedWork W2059229723 @default.
- W2011298300 hasRelatedWork W2061715753 @default.
- W2011298300 hasRelatedWork W2064984169 @default.
- W2011298300 hasRelatedWork W2071688816 @default.
- W2011298300 hasVolume "155" @default.
- W2011298300 isParatext "false" @default.
- W2011298300 isRetracted "false" @default.
- W2011298300 magId "2011298300" @default.
- W2011298300 workType "article" @default.