Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011299477> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2011299477 endingPage "18" @default.
- W2011299477 startingPage "12" @default.
- W2011299477 abstract "We investigated the antagonistic properties of several derivatives of beta-phenylethylamine at pre- and postsynaptic alpha-adrenoceptors (alpha 2 and alpha 1, respectively) using strips of rabbit pulmonary arteries preincubated with [3H]noradrenaline. The parent compound, BE 1726 [2-(beta-phenylethyl-aminomethyl)-tetralone], produced an increase in electrically evoked 3H overflow and in inhibition of the electrically evoked increase in tension; both effects occurred in the same concentration range. Substitution on the benzene ring of the beta-phenylethylamine moiety with a hydroxy (e.g., BE 2254, a well-characterized alpha 1-adrenoceptor antagonist) and/or methoxy group did not substantially alter the presynaptic potency, but considerably increased the potency at postsynaptic sites (some of the derivatives were as potent as prazosin). beta-Hydroxy substitution on the aliphatic chain selectively decreased the presynaptic potency. Hence, these changes in structure resulted in a marked preference for action at postsynaptic sites which was, however, less pronounced than that of prazosin. The increasing effect of the drugs on 3H overflow was attenuated by clonidine, and the compounds produced parallel shifts to the right of the concentration-response curve of noradrenaline for its contractile action, suggesting that the pre- and postsynaptic effects were mediated via alpha-adrenoceptors. In conclusion, strong and preferential blockade of alpha 1-adrenoceptors can be achieved by derivatives of beta-phenylethylamine, N-substituted with methyl-alpha-tetralone." @default.
- W2011299477 created "2016-06-24" @default.
- W2011299477 creator A5011874549 @default.
- W2011299477 creator A5022228935 @default.
- W2011299477 creator A5046138442 @default.
- W2011299477 date "1983-01-01" @default.
- W2011299477 modified "2023-09-27" @default.
- W2011299477 title "Preferential Blockade of α1-Adrenoceptors in the Rabbit Pulmonary Artery by Derivatives of β-Phenylethylamine Chemically Related to BE 2254 (HEAT)" @default.
- W2011299477 doi "https://doi.org/10.1097/00005344-198301000-00002" @default.
- W2011299477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6186846" @default.
- W2011299477 hasPublicationYear "1983" @default.
- W2011299477 type Work @default.
- W2011299477 sameAs 2011299477 @default.
- W2011299477 citedByCount "5" @default.
- W2011299477 countsByYear W20112994772021 @default.
- W2011299477 crossrefType "journal-article" @default.
- W2011299477 hasAuthorship W2011299477A5011874549 @default.
- W2011299477 hasAuthorship W2011299477A5022228935 @default.
- W2011299477 hasAuthorship W2011299477A5046138442 @default.
- W2011299477 hasConcept C159110408 @default.
- W2011299477 hasConcept C170493617 @default.
- W2011299477 hasConcept C185592680 @default.
- W2011299477 hasConcept C197341189 @default.
- W2011299477 hasConcept C202751555 @default.
- W2011299477 hasConcept C2775944032 @default.
- W2011299477 hasConcept C2776885963 @default.
- W2011299477 hasConcept C2780648677 @default.
- W2011299477 hasConcept C49453240 @default.
- W2011299477 hasConcept C55493867 @default.
- W2011299477 hasConcept C57992300 @default.
- W2011299477 hasConcept C64943373 @default.
- W2011299477 hasConcept C71240020 @default.
- W2011299477 hasConcept C71924100 @default.
- W2011299477 hasConcept C86803240 @default.
- W2011299477 hasConcept C98274493 @default.
- W2011299477 hasConceptScore W2011299477C159110408 @default.
- W2011299477 hasConceptScore W2011299477C170493617 @default.
- W2011299477 hasConceptScore W2011299477C185592680 @default.
- W2011299477 hasConceptScore W2011299477C197341189 @default.
- W2011299477 hasConceptScore W2011299477C202751555 @default.
- W2011299477 hasConceptScore W2011299477C2775944032 @default.
- W2011299477 hasConceptScore W2011299477C2776885963 @default.
- W2011299477 hasConceptScore W2011299477C2780648677 @default.
- W2011299477 hasConceptScore W2011299477C49453240 @default.
- W2011299477 hasConceptScore W2011299477C55493867 @default.
- W2011299477 hasConceptScore W2011299477C57992300 @default.
- W2011299477 hasConceptScore W2011299477C64943373 @default.
- W2011299477 hasConceptScore W2011299477C71240020 @default.
- W2011299477 hasConceptScore W2011299477C71924100 @default.
- W2011299477 hasConceptScore W2011299477C86803240 @default.
- W2011299477 hasConceptScore W2011299477C98274493 @default.
- W2011299477 hasIssue "1" @default.
- W2011299477 hasLocation W20112994771 @default.
- W2011299477 hasLocation W20112994772 @default.
- W2011299477 hasOpenAccess W2011299477 @default.
- W2011299477 hasPrimaryLocation W20112994771 @default.
- W2011299477 hasRelatedWork W1163905850 @default.
- W2011299477 hasRelatedWork W1589922914 @default.
- W2011299477 hasRelatedWork W1964993772 @default.
- W2011299477 hasRelatedWork W2022129581 @default.
- W2011299477 hasRelatedWork W2161277565 @default.
- W2011299477 hasRelatedWork W2416023448 @default.
- W2011299477 hasRelatedWork W2463848598 @default.
- W2011299477 hasRelatedWork W3082462337 @default.
- W2011299477 hasRelatedWork W3191961327 @default.
- W2011299477 hasRelatedWork W4231546689 @default.
- W2011299477 hasVolume "5" @default.
- W2011299477 isParatext "false" @default.
- W2011299477 isRetracted "false" @default.
- W2011299477 magId "2011299477" @default.
- W2011299477 workType "article" @default.