Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011303018> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2011303018 endingPage "43" @default.
- W2011303018 startingPage "38" @default.
- W2011303018 abstract "In this study we demonstrate that physiologic concentrations of genistein are sufficient to mediate agonism and to reverse the repressive effects of 4-hydroxytamoxifen on estrogen receptor (ER alpha)-responsive reporter genes. We also show that overexpression of the steroid receptor coactivator (SRC-1) potentiates transactivation by genistein-activated ER alpha and that coexpression of CBP (the cAMP response element binding protein coactivator) synergistically increases this signal. Exogenous expression of a nuclear receptor corepressor (NCoR) was, however, unable to alter genistein-mediated transactivation. In in vitro binding assays, we show that genistein, but not 4-hydroxytamoxifen, induces a direct interaction between radiolabeled ER alpha and a GST-SRC-1 fusion protein. More importantly, coincubation with genistein and 4-hydroxytamoxifen or genistein treatment following preincubation of the ER with 4-hydroxytamoxifen also resulted in a strong physical interaction with SRC-1. These findings imply that genistein-induced shifts in the coregulator status of ER alpha may be involved in transcriptional regulation and suggest that tamoxifen-mediated antagonism at ER-dependent genes is sensitive to attenuation by low levels of genistein." @default.
- W2011303018 created "2016-06-24" @default.
- W2011303018 creator A5011082221 @default.
- W2011303018 creator A5016308160 @default.
- W2011303018 creator A5052979097 @default.
- W2011303018 date "1998-12-01" @default.
- W2011303018 modified "2023-09-25" @default.
- W2011303018 title "Genistein-Mediated Attenuation of Tamoxifen-Induced Antagonism from Estrogen Receptor-Regulated Genes" @default.
- W2011303018 doi "https://doi.org/10.1006/bbrc.1998.9751" @default.
- W2011303018 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9875216" @default.
- W2011303018 hasPublicationYear "1998" @default.
- W2011303018 type Work @default.
- W2011303018 sameAs 2011303018 @default.
- W2011303018 citedByCount "42" @default.
- W2011303018 countsByYear W20113030182012 @default.
- W2011303018 countsByYear W20113030182013 @default.
- W2011303018 countsByYear W20113030182015 @default.
- W2011303018 countsByYear W20113030182016 @default.
- W2011303018 countsByYear W20113030182018 @default.
- W2011303018 crossrefType "journal-article" @default.
- W2011303018 hasAuthorship W2011303018A5011082221 @default.
- W2011303018 hasAuthorship W2011303018A5016308160 @default.
- W2011303018 hasAuthorship W2011303018A5052979097 @default.
- W2011303018 hasConcept C104317684 @default.
- W2011303018 hasConcept C121608353 @default.
- W2011303018 hasConcept C1292079 @default.
- W2011303018 hasConcept C134018914 @default.
- W2011303018 hasConcept C146777309 @default.
- W2011303018 hasConcept C150194340 @default.
- W2011303018 hasConcept C161733203 @default.
- W2011303018 hasConcept C172313692 @default.
- W2011303018 hasConcept C185592680 @default.
- W2011303018 hasConcept C195598365 @default.
- W2011303018 hasConcept C203966977 @default.
- W2011303018 hasConcept C2778298627 @default.
- W2011303018 hasConcept C502942594 @default.
- W2011303018 hasConcept C530470458 @default.
- W2011303018 hasConcept C54355233 @default.
- W2011303018 hasConcept C55493867 @default.
- W2011303018 hasConcept C63932345 @default.
- W2011303018 hasConcept C77445288 @default.
- W2011303018 hasConcept C84606932 @default.
- W2011303018 hasConcept C86339819 @default.
- W2011303018 hasConcept C86803240 @default.
- W2011303018 hasConcept C91977512 @default.
- W2011303018 hasConcept C96307122 @default.
- W2011303018 hasConceptScore W2011303018C104317684 @default.
- W2011303018 hasConceptScore W2011303018C121608353 @default.
- W2011303018 hasConceptScore W2011303018C1292079 @default.
- W2011303018 hasConceptScore W2011303018C134018914 @default.
- W2011303018 hasConceptScore W2011303018C146777309 @default.
- W2011303018 hasConceptScore W2011303018C150194340 @default.
- W2011303018 hasConceptScore W2011303018C161733203 @default.
- W2011303018 hasConceptScore W2011303018C172313692 @default.
- W2011303018 hasConceptScore W2011303018C185592680 @default.
- W2011303018 hasConceptScore W2011303018C195598365 @default.
- W2011303018 hasConceptScore W2011303018C203966977 @default.
- W2011303018 hasConceptScore W2011303018C2778298627 @default.
- W2011303018 hasConceptScore W2011303018C502942594 @default.
- W2011303018 hasConceptScore W2011303018C530470458 @default.
- W2011303018 hasConceptScore W2011303018C54355233 @default.
- W2011303018 hasConceptScore W2011303018C55493867 @default.
- W2011303018 hasConceptScore W2011303018C63932345 @default.
- W2011303018 hasConceptScore W2011303018C77445288 @default.
- W2011303018 hasConceptScore W2011303018C84606932 @default.
- W2011303018 hasConceptScore W2011303018C86339819 @default.
- W2011303018 hasConceptScore W2011303018C86803240 @default.
- W2011303018 hasConceptScore W2011303018C91977512 @default.
- W2011303018 hasConceptScore W2011303018C96307122 @default.
- W2011303018 hasIssue "1" @default.
- W2011303018 hasLocation W20113030181 @default.
- W2011303018 hasLocation W20113030182 @default.
- W2011303018 hasOpenAccess W2011303018 @default.
- W2011303018 hasPrimaryLocation W20113030181 @default.
- W2011303018 hasRelatedWork W1990579890 @default.
- W2011303018 hasRelatedWork W2011303018 @default.
- W2011303018 hasRelatedWork W2018038828 @default.
- W2011303018 hasRelatedWork W2050018101 @default.
- W2011303018 hasRelatedWork W2063125253 @default.
- W2011303018 hasRelatedWork W2074087098 @default.
- W2011303018 hasRelatedWork W2088158485 @default.
- W2011303018 hasRelatedWork W2101936214 @default.
- W2011303018 hasRelatedWork W2111611782 @default.
- W2011303018 hasRelatedWork W2119377878 @default.
- W2011303018 hasVolume "253" @default.
- W2011303018 isParatext "false" @default.
- W2011303018 isRetracted "false" @default.
- W2011303018 magId "2011303018" @default.
- W2011303018 workType "article" @default.