Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011303949> ?p ?o ?g. }
- W2011303949 endingPage "851" @default.
- W2011303949 startingPage "845" @default.
- W2011303949 abstract "To explore the mechanism of MAP kinase activation in adipocytes, we examined the possible involvement of several candidate signaling proteins. MAP kinase activity was markedly increased 2-4 min after treatment with insulin and declined to basal levels after 20 min. The insulin-dependent tyrosine phosphorylation of IRS-1 in the internal membrane and its association with phosphatidylinositol 3 (PI3) kinase preceded MAP kinase activation. There was little or no tyrosine phosphorylation of Shc or association of Grb2 with Shc or IRS-1. Specific PI3 kinase inhibitors blocked the insulin-mediated activation of MAP kinase. They also decreased the activation of MAP kinase by PMA and EGF but to a much lesser extent. Insulin induced phosphorylation of AKT on serine/threonine residues, and its effect could be blocked by PI3 kinase inhibitors. These results suggest that the insulin-dependent activation of MAP kinase in adipocytes is mediated by the IRS-1/PI3 kinase pathway but not by the Shc/Grb2/SOS pathway." @default.
- W2011303949 created "2016-06-24" @default.
- W2011303949 creator A5038898513 @default.
- W2011303949 creator A5054786425 @default.
- W2011303949 creator A5056846654 @default.
- W2011303949 creator A5059860261 @default.
- W2011303949 date "2000-08-01" @default.
- W2011303949 modified "2023-09-27" @default.
- W2011303949 title "Insulin Activation of Mitogen-Activated Protein (MAP) Kinase and Akt Is Phosphatidylinositol 3-Kinase-Dependent in Rat Adipocytes" @default.
- W2011303949 cites W1551443142 @default.
- W2011303949 cites W1570629413 @default.
- W2011303949 cites W1572009433 @default.
- W2011303949 cites W1573821584 @default.
- W2011303949 cites W1630763432 @default.
- W2011303949 cites W1665206156 @default.
- W2011303949 cites W1672057709 @default.
- W2011303949 cites W1689754237 @default.
- W2011303949 cites W1712871378 @default.
- W2011303949 cites W1926696092 @default.
- W2011303949 cites W1971475788 @default.
- W2011303949 cites W1976177239 @default.
- W2011303949 cites W1986381441 @default.
- W2011303949 cites W1986758681 @default.
- W2011303949 cites W2000367276 @default.
- W2011303949 cites W2009559018 @default.
- W2011303949 cites W2014702667 @default.
- W2011303949 cites W2039202467 @default.
- W2011303949 cites W2044868069 @default.
- W2011303949 cites W2058083313 @default.
- W2011303949 cites W2058138221 @default.
- W2011303949 cites W2061959038 @default.
- W2011303949 cites W2064801081 @default.
- W2011303949 cites W2066052044 @default.
- W2011303949 cites W2076490210 @default.
- W2011303949 cites W2089889881 @default.
- W2011303949 cites W2099677091 @default.
- W2011303949 cites W2100837269 @default.
- W2011303949 cites W2111295274 @default.
- W2011303949 cites W2122000735 @default.
- W2011303949 cites W2129413410 @default.
- W2011303949 cites W2141608854 @default.
- W2011303949 cites W2143873575 @default.
- W2011303949 cites W2286800257 @default.
- W2011303949 cites W28018459 @default.
- W2011303949 cites W4251148712 @default.
- W2011303949 cites W89084389 @default.
- W2011303949 doi "https://doi.org/10.1006/bbrc.2000.3208" @default.
- W2011303949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10924365" @default.
- W2011303949 hasPublicationYear "2000" @default.
- W2011303949 type Work @default.
- W2011303949 sameAs 2011303949 @default.
- W2011303949 citedByCount "16" @default.
- W2011303949 countsByYear W20113039492012 @default.
- W2011303949 countsByYear W20113039492013 @default.
- W2011303949 countsByYear W20113039492014 @default.
- W2011303949 countsByYear W20113039492016 @default.
- W2011303949 crossrefType "journal-article" @default.
- W2011303949 hasAuthorship W2011303949A5038898513 @default.
- W2011303949 hasAuthorship W2011303949A5054786425 @default.
- W2011303949 hasAuthorship W2011303949A5056846654 @default.
- W2011303949 hasAuthorship W2011303949A5059860261 @default.
- W2011303949 hasConcept C112446052 @default.
- W2011303949 hasConcept C11960822 @default.
- W2011303949 hasConcept C124160383 @default.
- W2011303949 hasConcept C132149769 @default.
- W2011303949 hasConcept C134018914 @default.
- W2011303949 hasConcept C137361374 @default.
- W2011303949 hasConcept C138227536 @default.
- W2011303949 hasConcept C159479382 @default.
- W2011303949 hasConcept C163035849 @default.
- W2011303949 hasConcept C185592680 @default.
- W2011303949 hasConcept C2777391703 @default.
- W2011303949 hasConcept C2779306644 @default.
- W2011303949 hasConcept C59143045 @default.
- W2011303949 hasConcept C75217442 @default.
- W2011303949 hasConcept C82495950 @default.
- W2011303949 hasConcept C86803240 @default.
- W2011303949 hasConcept C90934575 @default.
- W2011303949 hasConcept C91734924 @default.
- W2011303949 hasConcept C95444343 @default.
- W2011303949 hasConcept C97029542 @default.
- W2011303949 hasConceptScore W2011303949C112446052 @default.
- W2011303949 hasConceptScore W2011303949C11960822 @default.
- W2011303949 hasConceptScore W2011303949C124160383 @default.
- W2011303949 hasConceptScore W2011303949C132149769 @default.
- W2011303949 hasConceptScore W2011303949C134018914 @default.
- W2011303949 hasConceptScore W2011303949C137361374 @default.
- W2011303949 hasConceptScore W2011303949C138227536 @default.
- W2011303949 hasConceptScore W2011303949C159479382 @default.
- W2011303949 hasConceptScore W2011303949C163035849 @default.
- W2011303949 hasConceptScore W2011303949C185592680 @default.
- W2011303949 hasConceptScore W2011303949C2777391703 @default.
- W2011303949 hasConceptScore W2011303949C2779306644 @default.
- W2011303949 hasConceptScore W2011303949C59143045 @default.
- W2011303949 hasConceptScore W2011303949C75217442 @default.
- W2011303949 hasConceptScore W2011303949C82495950 @default.
- W2011303949 hasConceptScore W2011303949C86803240 @default.
- W2011303949 hasConceptScore W2011303949C90934575 @default.