FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011306547> ?p ?o ?g. }

• W2011306547 endingPage "248" @default.
• W2011306547 startingPage "232" @default.
• W2011306547 abstract "In a dose-finding study with an active control, several doses of a new drug are compared with an established drug (the so-called active control). One goal of such studies is to characterize the dose-response relationship and to find the smallest target dose concentration d(*), which leads to the same efficacy as the active control. For this purpose, the intersection point of the mean dose-response function with the expected efficacy of the active control has to be estimated. The focus of this paper is a cubic spline-based method for deriving an estimator of the target dose without assuming a specific dose-response function. Furthermore, the construction of a spline-based bootstrap CI is described. Estimator and CI are compared with other flexible and parametric methods such as linear spline interpolation as well as maximum likelihood regression in simulation studies motivated by a real clinical trial. Also, design considerations for the cubic spline approach with focus on bias minimization are presented. Although the spline-based point estimator can be biased, designs can be chosen to minimize and reasonably limit the maximum absolute bias. Furthermore, the coverage probability of the cubic spline approach is satisfactory, especially for bias minimal designs." @default.
• W2011306547 created "2016-06-24" @default.
• W2011306547 creator A5008233479 @default.
• W2011306547 creator A5009871877 @default.
• W2011306547 creator A5027112624 @default.
• W2011306547 creator A5044529842 @default.
• W2011306547 creator A5057325416 @default.
• W2011306547 date "2014-10-16" @default.
• W2011306547 modified "2023-10-06" @default.
• W2011306547 title "Spline‐based procedures for dose‐finding studies with active control" @default.
• W2011306547 cites W1828001519 @default.
• W2011306547 cites W1973002971 @default.
• W2011306547 cites W1974356961 @default.
• W2011306547 cites W1989527938 @default.
• W2011306547 cites W1994654755 @default.
• W2011306547 cites W1998413407 @default.
• W2011306547 cites W2003223511 @default.
• W2011306547 cites W2005178985 @default.
• W2011306547 cites W2008545760 @default.
• W2011306547 cites W2015449478 @default.
• W2011306547 cites W2015987000 @default.
• W2011306547 cites W2032489711 @default.
• W2011306547 cites W2044385716 @default.
• W2011306547 cites W2071835038 @default.
• W2011306547 cites W2074942313 @default.
• W2011306547 cites W2080376342 @default.
• W2011306547 cites W2094952568 @default.
• W2011306547 cites W2102434880 @default.
• W2011306547 cites W2103861636 @default.
• W2011306547 cites W2115217290 @default.
• W2011306547 cites W2117897510 @default.
• W2011306547 cites W2124562077 @default.
• W2011306547 cites W2125186811 @default.
• W2011306547 cites W2129986919 @default.
• W2011306547 cites W2160140338 @default.
• W2011306547 cites W2164538768 @default.
• W2011306547 cites W2169609216 @default.
• W2011306547 cites W2336346210 @default.
• W2011306547 cites W4229628595 @default.
• W2011306547 doi "https://doi.org/10.1002/sim.6320" @default.
• W2011306547 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4288315" @default.
• W2011306547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25319931" @default.
• W2011306547 hasPublicationYear "2014" @default.
• W2011306547 type Work @default.
• W2011306547 sameAs 2011306547 @default.
• W2011306547 citedByCount "6" @default.
• W2011306547 countsByYear W20113065472015 @default.
• W2011306547 countsByYear W20113065472017 @default.
• W2011306547 countsByYear W20113065472018 @default.
• W2011306547 countsByYear W20113065472021 @default.
• W2011306547 crossrefType "journal-article" @default.
• W2011306547 hasAuthorship W2011306547A5008233479 @default.
• W2011306547 hasAuthorship W2011306547A5009871877 @default.
• W2011306547 hasAuthorship W2011306547A5027112624 @default.
• W2011306547 hasAuthorship W2011306547A5044529842 @default.
• W2011306547 hasAuthorship W2011306547A5057325416 @default.
• W2011306547 hasBestOaLocation W20113065472 @default.
• W2011306547 hasConcept C10390562 @default.
• W2011306547 hasConcept C105795698 @default.
• W2011306547 hasConcept C107457265 @default.
• W2011306547 hasConcept C117251300 @default.
• W2011306547 hasConcept C126255220 @default.
• W2011306547 hasConcept C127413603 @default.
• W2011306547 hasConcept C185429906 @default.
• W2011306547 hasConcept C205203396 @default.
• W2011306547 hasConcept C28826006 @default.
• W2011306547 hasConcept C31447003 @default.
• W2011306547 hasConcept C33923547 @default.
• W2011306547 hasConcept C41008148 @default.
• W2011306547 hasConcept C66938386 @default.
• W2011306547 hasConcept C93132110 @default.
• W2011306547 hasConceptScore W2011306547C10390562 @default.
• W2011306547 hasConceptScore W2011306547C105795698 @default.
• W2011306547 hasConceptScore W2011306547C107457265 @default.
• W2011306547 hasConceptScore W2011306547C117251300 @default.
• W2011306547 hasConceptScore W2011306547C126255220 @default.
• W2011306547 hasConceptScore W2011306547C127413603 @default.
• W2011306547 hasConceptScore W2011306547C185429906 @default.
• W2011306547 hasConceptScore W2011306547C205203396 @default.
• W2011306547 hasConceptScore W2011306547C28826006 @default.
• W2011306547 hasConceptScore W2011306547C31447003 @default.
• W2011306547 hasConceptScore W2011306547C33923547 @default.
• W2011306547 hasConceptScore W2011306547C41008148 @default.
• W2011306547 hasConceptScore W2011306547C66938386 @default.
• W2011306547 hasConceptScore W2011306547C93132110 @default.
• W2011306547 hasIssue "2" @default.
• W2011306547 hasLocation W20113065471 @default.
• W2011306547 hasLocation W20113065472 @default.
• W2011306547 hasLocation W20113065473 @default.
• W2011306547 hasLocation W20113065474 @default.
• W2011306547 hasLocation W20113065475 @default.
• W2011306547 hasOpenAccess W2011306547 @default.
• W2011306547 hasPrimaryLocation W20113065471 @default.
• W2011306547 hasRelatedWork W1975728046 @default.
• W2011306547 hasRelatedWork W1997342009 @default.
• W2011306547 hasRelatedWork W2018229429 @default.
• W2011306547 hasRelatedWork W2070774473 @default.
• W2011306547 hasRelatedWork W2072793008 @default.

• next