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• W2011306587 abstract "Agonists of liver X receptors (LXR) α and β are important regulators of cholesterol metabolism, but agonism of the LXRα subtype appears to cause hepatic lipogenesis, suggesting LXRβ-selective activators are attractive new lipid lowering drugs. In this work, pharmacophore modeling and shape-based virtual screening were combined to predict new LXRβ-selective ligands. Out of the 10 predicted compounds, three displayed significant LXR activity. Two activated both LXR subtypes. The third compound activated LXRβ 1.8-fold over LXRα." @default.
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• W2011306587 date "2014-02-06" @default.
• W2011306587 modified "2023-09-24" @default.
• W2011306587 title "Discovery of New Liver X Receptor Agonists by Pharmacophore Modeling and Shape-Based Virtual Screening" @default.
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• W2011306587 doi "https://doi.org/10.1021/ci400682b" @default.
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