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• W2011307558 abstract "The novel immunomodulator FTY720 causes lymphocytes from peripheral blood to accumulate in lymphoid tissues. In vivo, FTY720 is phosphorylated to FTY720-P, which binds to the sphingosine 1-phosphate receptor S1P1. So far, it has been unclear where FTY720-P is produced. We demonstrate that platelets efficiently convert FTY720 to FTY720-P and release it into the extracellular space. This release is mostly independent of platelet activation, but is slightly increased upon thrombin stimulation. These results suggest that platelets are a major source of plasma FTY720-P, and that FTY720-P release is mediated by two different transporters." @default.
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• W2011307558 date "2007-07-01" @default.
• W2011307558 modified "2023-09-26" @default.
• W2011307558 title "The immunomodulator FTY720 is phosphorylated and released from platelets" @default.
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• W2011307558 doi "https://doi.org/10.1016/j.ejphar.2007.04.053" @default.
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