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- W2011308768 abstract "The influence of intracerebroventricular (i.c.v.) injections of (S)-3,5-dihydroxyphenyl-glycine (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors (mGluRs), on the activity of the central nervous system was examined in male rats. (S)-3,5-DHPG at doses of 25, 50 and 100 nmol significantly attenuated crossings of squares and rearings, but not bar approaches, in an 'open field' test and failed to change apomorphine-induced stereotypy. (S)-3,5-DHPG at the above doses, given immediately after the learning trial, significantly facilitated the consolidation process in a passive avoidance situation, but given before the learning trial and before the retention testing did not have any influence on acquisition and retrieval processes, respectively. Moreover, (S)-3,5-DHPG did not influence recognition memory evaluated in an object recognition test. These results may suggest that activation of group I mGluRs takes part in the consolidation process in affectively-motivated memory, but is probably not necessary for processing of recognition memory, and that (S)-3,5-DHPG memory facilitation seems to be independent of glutamatergic and dopaminergic interaction." @default.
- W2011308768 created "2016-06-24" @default.
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- W2011308768 date "2000-09-01" @default.
- W2011308768 modified "2023-09-25" @default.
- W2011308768 title "Behavioural activity of (S)-3,5-DHPG, a selective agonist of group I metabotropic glutamate receptors" @default.
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- W2011308768 doi "https://doi.org/10.1006/phrs.2000.0683" @default.
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