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- W2011309268 abstract "A series of molecular dynamics simulations have been used to investigate the nature of monomeric and dimeric insulin in aqueous solution. It is shown that in the absence of crystal contacts both monomeric and dimeric insulin have a high degree of intrinsic flexibility. Neither of the two monomer conformations of 2Zn crystalline insulin appears to be favored in solution nor is the asymmetry of the crystal dimer reduced in the absence of crystal contacts. A shift is observed in the relative positions of molecules 1 and 2 in the dimer compared with that found in the crystal, which may have consequences for the prediction of the effects of mutants in the monomer-monomer interface designed to alter the self-association properties of insulin." @default.
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- W2011309268 date "1991-11-01" @default.
- W2011309268 modified "2023-10-01" @default.
- W2011309268 title "Conformational flexibility of aqueous monomeric and dimeric insulin: a molecular dynamics study" @default.
- W2011309268 doi "https://doi.org/10.1021/bi00109a009" @default.
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