Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011313033> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2011313033 endingPage "27" @default.
- W2011313033 startingPage "27" @default.
- W2011313033 abstract "The innate immune response serves as a robust first line of defense against pathogens, protecting the host from infectious organisms in a rapid and antigen-independent manner. Viral infection activates the type I interferon (IFN-I) response, leading to the production of hundreds of interferon-stimulated genes (ISGs). Many of these ISG-encoded proteins restrict viral infection by a variety of mechanisms that inhibit different stages of the virus life cycle. Translation inhibition, which restricts the production of viral proteins and host factors required for viral replication, is a common cellular response to viral infection. The IFN-I response induces translation inhibition primarily through the expression of ISG-encoded proteins. These proteins employ a variety of mechanisms to inhibit either global or virus-specific translation, resulting in restriction of viral replication and dissemination. In this graphical review, we provide an overview of the critical role of ISG-encoded proteins in translational regulation during the IFN-I response and viral infection. We focus on the molecular mechanisms by which ISG-encoded proteins restrict viral translation, including blocking the assembly of the translation machinery and inducing RNA degradation." @default.
- W2011313033 created "2016-06-24" @default.
- W2011313033 creator A5024589162 @default.
- W2011313033 creator A5034750597 @default.
- W2011313033 creator A5050278412 @default.
- W2011313033 creator A5060457244 @default.
- W2011313033 creator A5065397632 @default.
- W2011313033 creator A5067742674 @default.
- W2011313033 creator A5069592485 @default.
- W2011313033 creator A5081778083 @default.
- W2011313033 creator A5083303245 @default.
- W2011313033 date "2012-05-01" @default.
- W2011313033 modified "2023-10-16" @default.
- W2011313033 title "A multi-dimensional RNAi screen reveals pathways controlling MHC Class II antigen presentation" @default.
- W2011313033 cites W2036062404 @default.
- W2011313033 doi "https://doi.org/10.1016/j.molimm.2012.02.073" @default.
- W2011313033 hasPublicationYear "2012" @default.
- W2011313033 type Work @default.
- W2011313033 sameAs 2011313033 @default.
- W2011313033 citedByCount "0" @default.
- W2011313033 crossrefType "journal-article" @default.
- W2011313033 hasAuthorship W2011313033A5024589162 @default.
- W2011313033 hasAuthorship W2011313033A5034750597 @default.
- W2011313033 hasAuthorship W2011313033A5050278412 @default.
- W2011313033 hasAuthorship W2011313033A5060457244 @default.
- W2011313033 hasAuthorship W2011313033A5065397632 @default.
- W2011313033 hasAuthorship W2011313033A5067742674 @default.
- W2011313033 hasAuthorship W2011313033A5069592485 @default.
- W2011313033 hasAuthorship W2011313033A5081778083 @default.
- W2011313033 hasAuthorship W2011313033A5083303245 @default.
- W2011313033 hasConcept C104317684 @default.
- W2011313033 hasConcept C105580179 @default.
- W2011313033 hasConcept C136449434 @default.
- W2011313033 hasConcept C140704245 @default.
- W2011313033 hasConcept C149364088 @default.
- W2011313033 hasConcept C159047783 @default.
- W2011313033 hasConcept C166703698 @default.
- W2011313033 hasConcept C2522874641 @default.
- W2011313033 hasConcept C2776090121 @default.
- W2011313033 hasConcept C2776178377 @default.
- W2011313033 hasConcept C2780879997 @default.
- W2011313033 hasConcept C2909928835 @default.
- W2011313033 hasConcept C54355233 @default.
- W2011313033 hasConcept C58475186 @default.
- W2011313033 hasConcept C67705224 @default.
- W2011313033 hasConcept C83464605 @default.
- W2011313033 hasConcept C86803240 @default.
- W2011313033 hasConcept C8891405 @default.
- W2011313033 hasConcept C95444343 @default.
- W2011313033 hasConceptScore W2011313033C104317684 @default.
- W2011313033 hasConceptScore W2011313033C105580179 @default.
- W2011313033 hasConceptScore W2011313033C136449434 @default.
- W2011313033 hasConceptScore W2011313033C140704245 @default.
- W2011313033 hasConceptScore W2011313033C149364088 @default.
- W2011313033 hasConceptScore W2011313033C159047783 @default.
- W2011313033 hasConceptScore W2011313033C166703698 @default.
- W2011313033 hasConceptScore W2011313033C2522874641 @default.
- W2011313033 hasConceptScore W2011313033C2776090121 @default.
- W2011313033 hasConceptScore W2011313033C2776178377 @default.
- W2011313033 hasConceptScore W2011313033C2780879997 @default.
- W2011313033 hasConceptScore W2011313033C2909928835 @default.
- W2011313033 hasConceptScore W2011313033C54355233 @default.
- W2011313033 hasConceptScore W2011313033C58475186 @default.
- W2011313033 hasConceptScore W2011313033C67705224 @default.
- W2011313033 hasConceptScore W2011313033C83464605 @default.
- W2011313033 hasConceptScore W2011313033C86803240 @default.
- W2011313033 hasConceptScore W2011313033C8891405 @default.
- W2011313033 hasConceptScore W2011313033C95444343 @default.
- W2011313033 hasIssue "1" @default.
- W2011313033 hasLocation W20113130331 @default.
- W2011313033 hasOpenAccess W2011313033 @default.
- W2011313033 hasPrimaryLocation W20113130331 @default.
- W2011313033 hasRelatedWork W1987349404 @default.
- W2011313033 hasRelatedWork W2009671413 @default.
- W2011313033 hasRelatedWork W2010825098 @default.
- W2011313033 hasRelatedWork W2066966091 @default.
- W2011313033 hasRelatedWork W2136046700 @default.
- W2011313033 hasRelatedWork W2142935324 @default.
- W2011313033 hasRelatedWork W2148114753 @default.
- W2011313033 hasRelatedWork W2167287447 @default.
- W2011313033 hasRelatedWork W2406270448 @default.
- W2011313033 hasRelatedWork W3120084339 @default.
- W2011313033 hasVolume "51" @default.
- W2011313033 isParatext "false" @default.
- W2011313033 isRetracted "false" @default.
- W2011313033 magId "2011313033" @default.
- W2011313033 workType "article" @default.