FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011314273> ?p ?o ?g. }

• W2011314273 endingPage "854" @default.
• W2011314273 startingPage "849" @default.
• W2011314273 abstract "The role of the vascular endothelial growth factor receptor-1 (VEGFR-1) in endothelial cell function is unclear. We have previously identified four tyrosine phosphorylation sites in the C-terminal tail of this receptor. We now show that the wild type VEGFR-1 expressed in porcine aortic endothelial (PAE/VEGFR-1) cells was able to transduce signals for increased DNA synthesis and proliferation. Tyrosine phosphorylation of phospholipase Cgamma (PLCgamma), tyrosine phosphatase SHP-2, Crk, and extracellular regulated kinases 1 and 2 (Erk1/2) was registered in response to VEGF-A treatment of the PAE/VEGFR-1 cells. VEGFR-1 mutated at Y1213, Y1242, and Y1333 were constructed and expressed in PAE cells, to the same level as that of PAE/VEGFR-1 cells. The affinities of the wild type and mutated receptors for VEGF-A(165) binding were similar. The mutated VEGFR-1 Y1213F expressed in PAE cells was kinase inactive. PAE cells expressing the mutated VEGFR-1 Y1242F and Y1333F receptors mediated increased tyrosine phosphorylation of PLCgamma in response to VEGF-A stimulation. However, these two mutant VEGFR-1 failed to mediate increased mitogenesis and were unable to stimulate increased tyrosine phosphorylation of SHP-2, Crk, and Erk1/2, indicating that the mutations lead to a perturbation in VEGF-A-induced signal transduction." @default.
• W2011314273 created "2016-06-24" @default.
• W2011314273 creator A5003411082 @default.
• W2011314273 creator A5047440889 @default.
• W2011314273 creator A5072547827 @default.
• W2011314273 date "2001-11-01" @default.
• W2011314273 modified "2023-09-26" @default.
• W2011314273 title "Signal transduction by VEGF receptor-1 wild type and mutant proteins" @default.
• W2011314273 cites W1507160997 @default.
• W2011314273 cites W1600542667 @default.
• W2011314273 cites W1969364502 @default.
• W2011314273 cites W1972821205 @default.
• W2011314273 cites W1982912692 @default.
• W2011314273 cites W1986559037 @default.
• W2011314273 cites W1991494112 @default.
• W2011314273 cites W2001880315 @default.
• W2011314273 cites W2017879489 @default.
• W2011314273 cites W2046516822 @default.
• W2011314273 cites W2071062791 @default.
• W2011314273 cites W2084947524 @default.
• W2011314273 cites W2088796595 @default.
• W2011314273 cites W2098728140 @default.
• W2011314273 cites W2141046053 @default.
• W2011314273 cites W2166156136 @default.
• W2011314273 cites W2168146767 @default.
• W2011314273 doi "https://doi.org/10.1016/s0898-6568(01)00209-1" @default.
• W2011314273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11583921" @default.
• W2011314273 hasPublicationYear "2001" @default.
• W2011314273 type Work @default.
• W2011314273 sameAs 2011314273 @default.
• W2011314273 citedByCount "38" @default.
• W2011314273 countsByYear W20113142732012 @default.
• W2011314273 countsByYear W20113142732013 @default.
• W2011314273 countsByYear W20113142732015 @default.
• W2011314273 countsByYear W20113142732019 @default.
• W2011314273 crossrefType "journal-article" @default.
• W2011314273 hasAuthorship W2011314273A5003411082 @default.
• W2011314273 hasAuthorship W2011314273A5047440889 @default.
• W2011314273 hasAuthorship W2011314273A5072547827 @default.
• W2011314273 hasConcept C101544691 @default.
• W2011314273 hasConcept C108636557 @default.
• W2011314273 hasConcept C11960822 @default.
• W2011314273 hasConcept C133570447 @default.
• W2011314273 hasConcept C153911025 @default.
• W2011314273 hasConcept C167734588 @default.
• W2011314273 hasConcept C170493617 @default.
• W2011314273 hasConcept C180361614 @default.
• W2011314273 hasConcept C183786373 @default.
• W2011314273 hasConcept C2775960820 @default.
• W2011314273 hasConcept C2777025900 @default.
• W2011314273 hasConcept C2777553839 @default.
• W2011314273 hasConcept C42362537 @default.
• W2011314273 hasConcept C502942594 @default.
• W2011314273 hasConcept C55493867 @default.
• W2011314273 hasConcept C62478195 @default.
• W2011314273 hasConcept C85528070 @default.
• W2011314273 hasConcept C86803240 @default.
• W2011314273 hasConcept C95444343 @default.
• W2011314273 hasConceptScore W2011314273C101544691 @default.
• W2011314273 hasConceptScore W2011314273C108636557 @default.
• W2011314273 hasConceptScore W2011314273C11960822 @default.
• W2011314273 hasConceptScore W2011314273C133570447 @default.
• W2011314273 hasConceptScore W2011314273C153911025 @default.
• W2011314273 hasConceptScore W2011314273C167734588 @default.
• W2011314273 hasConceptScore W2011314273C170493617 @default.
• W2011314273 hasConceptScore W2011314273C180361614 @default.
• W2011314273 hasConceptScore W2011314273C183786373 @default.
• W2011314273 hasConceptScore W2011314273C2775960820 @default.
• W2011314273 hasConceptScore W2011314273C2777025900 @default.
• W2011314273 hasConceptScore W2011314273C2777553839 @default.
• W2011314273 hasConceptScore W2011314273C42362537 @default.
• W2011314273 hasConceptScore W2011314273C502942594 @default.
• W2011314273 hasConceptScore W2011314273C55493867 @default.
• W2011314273 hasConceptScore W2011314273C62478195 @default.
• W2011314273 hasConceptScore W2011314273C85528070 @default.
• W2011314273 hasConceptScore W2011314273C86803240 @default.
• W2011314273 hasConceptScore W2011314273C95444343 @default.
• W2011314273 hasFunder F4320316588 @default.
• W2011314273 hasFunder F4320321491 @default.
• W2011314273 hasFunder F4320325957 @default.
• W2011314273 hasIssue "11" @default.
• W2011314273 hasLocation W20113142731 @default.
• W2011314273 hasLocation W20113142732 @default.
• W2011314273 hasOpenAccess W2011314273 @default.
• W2011314273 hasPrimaryLocation W20113142731 @default.
• W2011314273 hasRelatedWork W1537076792 @default.
• W2011314273 hasRelatedWork W1988628626 @default.
• W2011314273 hasRelatedWork W2019151336 @default.
• W2011314273 hasRelatedWork W2080005173 @default.
• W2011314273 hasRelatedWork W2096032969 @default.
• W2011314273 hasRelatedWork W2110789444 @default.
• W2011314273 hasRelatedWork W2121905156 @default.
• W2011314273 hasRelatedWork W2143406502 @default.
• W2011314273 hasRelatedWork W2441853607 @default.
• W2011314273 hasRelatedWork W4247927249 @default.
• W2011314273 hasVolume "13" @default.
• W2011314273 isParatext "false" @default.
• W2011314273 isRetracted "false" @default.

• next