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- W2011319711 abstract "Tachycardia has been used as an indirect measure of isoproterenol absorption in anesthetized dogs. It was rapidly absorbed by the mucous membrane of the small intestine, proximal colon, and rectum and best absorbed by the mucous membrane of the trachea. A ratio of approximately 7:1 was obtained when the activity from the trachea and rectum was compared. Isoproterenol was poorly absorbed in the empty stomach when the mucosal surface was at pH 1.5–4.0. The cardiac response to intravenous injection or infusion of isoproterenol through the femoral and the gastro-epiploic (portal) veins has been compared. A statistically significant and greater increase in the heart rate was obtained consistently from the femoral vein. This difference may be attributed to some inactivation of isoproterenol by the portalhepatic system. Tachycardia has been used as an indirect measure of isoproterenol absorption in anesthetized dogs. It was rapidly absorbed by the mucous membrane of the small intestine, proximal colon, and rectum and best absorbed by the mucous membrane of the trachea. A ratio of approximately 7:1 was obtained when the activity from the trachea and rectum was compared. Isoproterenol was poorly absorbed in the empty stomach when the mucosal surface was at pH 1.5–4.0. The cardiac response to intravenous injection or infusion of isoproterenol through the femoral and the gastro-epiploic (portal) veins has been compared. A statistically significant and greater increase in the heart rate was obtained consistently from the femoral vein. This difference may be attributed to some inactivation of isoproterenol by the portalhepatic system." @default.
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- W2011319711 date "1965-07-01" @default.
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- W2011319711 title "Absorption and Elimination Profile of Isoproterenol I" @default.
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- W2011319711 doi "https://doi.org/10.1002/jps.2600540704" @default.
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