FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011325395> ?p ?o ?g. }

• W2011325395 endingPage "5365" @default.
• W2011325395 startingPage "5360" @default.
• W2011325395 abstract "Aspergillus fumigatus is commonly associated with allergic bronchopulmonary aspergillosis in patients with severe asthma in which chronic airway neutrophilia predicts a poor outcome. We were able to recapitulate fungus-induced neutrophilic airway inflammation in a mouse model in our efforts to understand the underlying mechanisms. However, neutrophilia occurred in a mouse strain-selective fashion, providing us with an opportunity to perform a comparative study to elucidate the mechanisms involved. Here we show that TNF-α, largely produced by Ly6c + CD11b + dendritic cells (DCs), plays a central role in promoting IL-17A from CD4 + T cells and collaborating with it to induce airway neutrophilia. Compared with C57BL/6 mice, BALB/c mice displayed significantly more TNF-α–producing DCs and macrophages in the lung. Lung TNF-α levels were drastically reduced in CD11c-DTR BALB/c mice depleted of CD11c+ cells, and TNF-α–producing Ly6c + CD11b + cells were abolished in Dectin-1 −/− and MyD88 −/− BALB/c mice. TNF-α deficiency itself blunted accumulation of inflammatory Ly6c + CD11b + DCs. Also, lack of TNF-α decreased IL-17A but promoted IL-5 levels, switching inflammation from a neutrophil to eosinophil bias resembling that in C57BL/6 mice. The TNF-α low DCs in C57BL/6 mice contained more NF-κB p50 homodimers, which are strong repressors of TNF-α transcription. Functionally, collaboration between TNF-α and IL-17A triggered significantly higher levels of the neutrophil chemoattractants keratinocyte cytokine and macrophage inflammatory protein 2 in BALB/c mice. Our study identifies TNF-α as a molecular switch that orchestrates a sequence of events in DCs and CD4 T cells that promote neutrophilic airway inflammation." @default.
• W2011325395 created "2016-06-24" @default.
• W2011325395 creator A5010067541 @default.
• W2011325395 creator A5018553332 @default.
• W2011325395 creator A5022015777 @default.
• W2011325395 creator A5040784287 @default.
• W2011325395 creator A5044627775 @default.
• W2011325395 creator A5052689943 @default.
• W2011325395 creator A5057033838 @default.
• W2011325395 creator A5063111442 @default.
• W2011325395 creator A5064283293 @default.
• W2011325395 creator A5072110251 @default.
• W2011325395 creator A5073095750 @default.
• W2011325395 creator A5074919264 @default.
• W2011325395 creator A5078918979 @default.
• W2011325395 creator A5088065317 @default.
• W2011325395 date "2011-03-14" @default.
• W2011325395 modified "2023-10-16" @default.
• W2011325395 title "TNF-α from inflammatory dendritic cells (DCs) regulates lung IL-17A/IL-5 levels and neutrophilia versus eosinophilia during persistent fungal infection" @default.
• W2011325395 cites W1603094468 @default.
• W2011325395 cites W1911091032 @default.
• W2011325395 cites W1945512486 @default.
• W2011325395 cites W1964465182 @default.
• W2011325395 cites W1990083653 @default.
• W2011325395 cites W2000851235 @default.
• W2011325395 cites W2005047699 @default.
• W2011325395 cites W2005998335 @default.
• W2011325395 cites W2007539174 @default.
• W2011325395 cites W2038141921 @default.
• W2011325395 cites W2051954214 @default.
• W2011325395 cites W2053798956 @default.
• W2011325395 cites W2054605333 @default.
• W2011325395 cites W2057968053 @default.
• W2011325395 cites W2059149560 @default.
• W2011325395 cites W2062363040 @default.
• W2011325395 cites W2070597700 @default.
• W2011325395 cites W2072263302 @default.
• W2011325395 cites W2084509745 @default.
• W2011325395 cites W2094786750 @default.
• W2011325395 cites W2099039895 @default.
• W2011325395 cites W2105777265 @default.
• W2011325395 cites W2112866067 @default.
• W2011325395 cites W2114770406 @default.
• W2011325395 cites W2116937539 @default.
• W2011325395 cites W2122044177 @default.
• W2011325395 cites W2125105493 @default.
• W2011325395 cites W2128850053 @default.
• W2011325395 cites W2132938540 @default.
• W2011325395 cites W2135703618 @default.
• W2011325395 cites W2140571619 @default.
• W2011325395 cites W2147711737 @default.
• W2011325395 cites W2152782116 @default.
• W2011325395 cites W2152899800 @default.
• W2011325395 cites W2153911335 @default.
• W2011325395 cites W2158373279 @default.
• W2011325395 cites W2160702475 @default.
• W2011325395 cites W2160883911 @default.
• W2011325395 cites W2163539931 @default.
• W2011325395 cites W2166798957 @default.
• W2011325395 cites W2166822160 @default.
• W2011325395 cites W2169751144 @default.
• W2011325395 cites W2170566395 @default.
• W2011325395 cites W2314313322 @default.
• W2011325395 cites W4242171500 @default.
• W2011325395 cites W4245291408 @default.
• W2011325395 cites W4294250611 @default.
• W2011325395 doi "https://doi.org/10.1073/pnas.1015476108" @default.
• W2011325395 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3069210" @default.
• W2011325395 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21402950" @default.
• W2011325395 hasPublicationYear "2011" @default.
• W2011325395 type Work @default.
• W2011325395 sameAs 2011325395 @default.
• W2011325395 citedByCount "119" @default.
• W2011325395 countsByYear W20113253952012 @default.
• W2011325395 countsByYear W20113253952013 @default.
• W2011325395 countsByYear W20113253952014 @default.
• W2011325395 countsByYear W20113253952015 @default.
• W2011325395 countsByYear W20113253952016 @default.
• W2011325395 countsByYear W20113253952017 @default.
• W2011325395 countsByYear W20113253952018 @default.
• W2011325395 countsByYear W20113253952019 @default.
• W2011325395 countsByYear W20113253952020 @default.
• W2011325395 countsByYear W20113253952021 @default.
• W2011325395 countsByYear W20113253952022 @default.
• W2011325395 countsByYear W20113253952023 @default.
• W2011325395 crossrefType "journal-article" @default.
• W2011325395 hasAuthorship W2011325395A5010067541 @default.
• W2011325395 hasAuthorship W2011325395A5018553332 @default.
• W2011325395 hasAuthorship W2011325395A5022015777 @default.
• W2011325395 hasAuthorship W2011325395A5040784287 @default.
• W2011325395 hasAuthorship W2011325395A5044627775 @default.
• W2011325395 hasAuthorship W2011325395A5052689943 @default.
• W2011325395 hasAuthorship W2011325395A5057033838 @default.
• W2011325395 hasAuthorship W2011325395A5063111442 @default.
• W2011325395 hasAuthorship W2011325395A5064283293 @default.
• W2011325395 hasAuthorship W2011325395A5072110251 @default.
• W2011325395 hasAuthorship W2011325395A5073095750 @default.
• W2011325395 hasAuthorship W2011325395A5074919264 @default.

• next