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• W2011330353 abstract "This work is motivated by a demand for inexpensive, robust and reliable biochemical sensors with high signalreproducibility and long-term-stable sensitivity, especially for medical applications. Micro-fabricated sensors canprovide continuous monitoring and on-line control of analyte concentrations in ambient aqueous solutions. Thepiezoresistive biochemical sensor containing a special biocompatible polymer (hydrogel) with a sharp volume phasetransition in the neutral physiological pH range near 7.4 can detect a specific analyte, for example glucose. Thereby thehydrogel-based biochemical sensors are useful for the diagnosis and monitoring of diabetes. The response of the glucosesensitivehydrogel was studied at different regimes of the glucose concentration change and of the solution supply.Sensor response time and accuracy with which a sensor can track gradual changes in glucose was estimated.Additionally, the influence of various recommended sterilization methods on the gel swelling properties and on themechano-electrical transducer of the pH-sensors has been evaluated in order to choose the most optimal sterilizationmethod for the implantable sensors. It has been shown that there is no negative effect of gamma irradiation with a doseof 25.7 kGy on the hydrogel sensitivity. In order to achieve an optimum between sensor signal amplitude and sensorresponse time, corresponding calibration and measurement procedures have been proposed and evaluated for thechemical sensors." @default.
• W2011330353 created "2016-06-24" @default.
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• W2011330353 date "2010-03-25" @default.
• W2011330353 modified "2023-10-13" @default.
• W2011330353 title "Hydrogel-based piezoresistive biochemical microsensors" @default.
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• W2011330353 doi "https://doi.org/10.1117/12.847373" @default.
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