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• W2011340167 abstract "PDGF is a potent mitogen that initiates the proliferation of quiescent fibroblastic cells. EGF and somatomedin C (or insulin) can replace the requirement for plasma to function synergistically with PDGF to stimulate DNA synthesis. PDGF, EGF and somatomedin C control discrete cellular events in the cell cycle. Cyclic AMP can potentiate the effects of polypeptide mitogens. The down-regulation of EGF receptors by PDGF and cyclic AMP brings about a loss of the requirement for exogenous EGF. The transient treatment of density-arrested fibroblasts with PDGF allows better study of synergistic actions of PDGF and plasma-derived factors. These synergistic interactions are important to understand in determining how multiple growth factors regulate cellular proliferation." @default.
• W2011340167 created "2016-06-24" @default.
• W2011340167 creator A5029435674 @default.
• W2011340167 creator A5084286188 @default.
• W2011340167 date "1983-08-01" @default.
• W2011340167 modified "2023-09-27" @default.
• W2011340167 title "A model of cell cycle control: Sequential events regulated by growth factors" @default.
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• W2011340167 doi "https://doi.org/10.1016/0303-7207(83)90147-8" @default.
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