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- W2011346196 abstract "Alzheimer's disease (AD) and vascular disease represent the most common causes of dementia in the elderly, with estimates of over 35 million individuals suffering from dementia, primarily of the Alzheimer's type, worldwide.[1] In the past 30 years, there has been a proliferation of imaging techniques to examine structural and functional brain changes associated with dementia as well as to identify the biomarkers indicative of molecular pathology and neuronal injury in neurologic disease. Advancements in magnetic resonance imaging (MRI; i.e. diffusion tensor imaging, fractional anisotropy, anatomic volumetric renderings) and nuclear medicine [i.e. F-18 fluorodeoxyglucose (FDG)-positron emission tomography, single-photon emission computed tomography (SPECT), β-amyloid labeled tracers Pittsburg compound B (PIB)] have presented researchers with tools to scaffold on their existing knowledge of the clinical and pathological hallmarks of dementia. Goals of imaging techniques include tracking and staging of the disease process, differential diagnosis, identification of prodromal stages of neurodegeneration and the detection of co-morbid conditions in the elderly, such as idiopathic normal pressure hydrocephalus (INPH). Examination of biomarkers can identify individuals at risk for developing dementia, aid in differential diagnosis, and provide confirmation of molecular pathology and neuronal injury. However, currently, advanced imaging tools and biomarker analyses are reserved primarily for research, with limited clinical application.[10,14]" @default.
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- W2011346196 date "2011-01-01" @default.
- W2011346196 modified "2023-09-27" @default.
- W2011346196 title "Closing the gap between research techniques and clinical practice in the treatment of dementia" @default.
- W2011346196 doi "https://doi.org/10.4103/2152-7806.90030" @default.
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