Matches in SemOpenAlex for { <https://semopenalex.org/work/W2011352595> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2011352595 endingPage "560" @default.
- W2011352595 startingPage "555" @default.
- W2011352595 abstract "When cells within the intrapulmonary compartment are exposed to pathogens or their products such as lipopolysaccharide, they produce CXC chemokines in order to attract circulating neutrophils into the lower respiratory tract. Previous studies have shown that as neutrophils (PMNs) enter the lung, bronchoalveolar lavage (BAL) chemokine levels are decreased. In this study, we determined the intrapulmonary and systemic responses to two important rat chemokines, cytokine-induced neutrophil chemoattractant (CINC) and macrophage inflammatory protein-2 (MIP-2), to intratracheal (i.t.) LPS (100 μg in 0.5 mL of phosphate-buffered saline) under neutropenic (cyclophosphamide [CPA]) and neutrophilic (G-CSF) conditions. By 4 h after i.t. LPS, CPA pretreatment decreased PMN recruitment 83% and G-CSF increased PMN recruitment 91% compared with recruitment into the lung in vehicle-pretreated rats (42.7 ± 19.3 million PMNs). Neutropenic rats had increased CINC and MIP-2 concentrations in BAL fluid 4 h after i.t. LPS when compared with levels seen in vehicle controls (P < 0.05). In vitro LPS-stimulated chemokine production by alveolar macrophages obtained from CPA- and vehicle-pretreated animals did not differ. The increase in BAL fluid chemokine levels in neutropenic rats corresponded to increased chemotaxis of neutrophils to BAL fluid from CPA-pretreated rats as compared with the chemotaxis response of PMN to BAL fluid from vehicle-pretreated rats. In contrast, G-CSF enhancement of neutrophil recruitment decreased chemotactic activity of BAL fluid collected 4 h after i.t. LPS. These data show that as neutrophils are recruited into the lung, they alter chemokine levels, which most likely serves to down-regulate the inflammatory response." @default.
- W2011352595 created "2016-06-24" @default.
- W2011352595 creator A5029247654 @default.
- W2011352595 creator A5055151897 @default.
- W2011352595 creator A5058940883 @default.
- W2011352595 creator A5073932029 @default.
- W2011352595 creator A5086871896 @default.
- W2011352595 date "2002-12-01" @default.
- W2011352595 modified "2023-10-12" @default.
- W2011352595 title "Neutrophil Modulation of the Pulmonary Chemokine Response to Lipopolysaccharide" @default.
- W2011352595 cites W1501778305 @default.
- W2011352595 cites W1506049383 @default.
- W2011352595 cites W1970923760 @default.
- W2011352595 cites W1972874692 @default.
- W2011352595 cites W1975212779 @default.
- W2011352595 cites W1999298222 @default.
- W2011352595 cites W2000932116 @default.
- W2011352595 cites W2003951221 @default.
- W2011352595 cites W2009000520 @default.
- W2011352595 cites W2040018862 @default.
- W2011352595 cites W2050946282 @default.
- W2011352595 cites W2054519973 @default.
- W2011352595 cites W2092877182 @default.
- W2011352595 cites W2101299878 @default.
- W2011352595 cites W2108129910 @default.
- W2011352595 cites W2114819441 @default.
- W2011352595 cites W2123037720 @default.
- W2011352595 cites W2144689930 @default.
- W2011352595 cites W2147657681 @default.
- W2011352595 cites W2152434300 @default.
- W2011352595 cites W2185008416 @default.
- W2011352595 cites W2338448307 @default.
- W2011352595 cites W2411164904 @default.
- W2011352595 cites W2038183969 @default.
- W2011352595 doi "https://doi.org/10.1097/00024382-200212000-00012" @default.
- W2011352595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12462565" @default.
- W2011352595 hasPublicationYear "2002" @default.
- W2011352595 type Work @default.
- W2011352595 sameAs 2011352595 @default.
- W2011352595 citedByCount "26" @default.
- W2011352595 countsByYear W20113525952012 @default.
- W2011352595 countsByYear W20113525952015 @default.
- W2011352595 crossrefType "journal-article" @default.
- W2011352595 hasAuthorship W2011352595A5029247654 @default.
- W2011352595 hasAuthorship W2011352595A5055151897 @default.
- W2011352595 hasAuthorship W2011352595A5058940883 @default.
- W2011352595 hasAuthorship W2011352595A5073932029 @default.
- W2011352595 hasAuthorship W2011352595A5086871896 @default.
- W2011352595 hasBestOaLocation W20113525951 @default.
- W2011352595 hasConcept C126322002 @default.
- W2011352595 hasConcept C13373296 @default.
- W2011352595 hasConcept C170493617 @default.
- W2011352595 hasConcept C185592680 @default.
- W2011352595 hasConcept C198677920 @default.
- W2011352595 hasConcept C203014093 @default.
- W2011352595 hasConcept C2776914184 @default.
- W2011352595 hasConcept C2777714996 @default.
- W2011352595 hasConcept C2777961210 @default.
- W2011352595 hasConcept C2778690821 @default.
- W2011352595 hasConcept C2778754761 @default.
- W2011352595 hasConcept C54166955 @default.
- W2011352595 hasConcept C68324877 @default.
- W2011352595 hasConcept C71924100 @default.
- W2011352595 hasConceptScore W2011352595C126322002 @default.
- W2011352595 hasConceptScore W2011352595C13373296 @default.
- W2011352595 hasConceptScore W2011352595C170493617 @default.
- W2011352595 hasConceptScore W2011352595C185592680 @default.
- W2011352595 hasConceptScore W2011352595C198677920 @default.
- W2011352595 hasConceptScore W2011352595C203014093 @default.
- W2011352595 hasConceptScore W2011352595C2776914184 @default.
- W2011352595 hasConceptScore W2011352595C2777714996 @default.
- W2011352595 hasConceptScore W2011352595C2777961210 @default.
- W2011352595 hasConceptScore W2011352595C2778690821 @default.
- W2011352595 hasConceptScore W2011352595C2778754761 @default.
- W2011352595 hasConceptScore W2011352595C54166955 @default.
- W2011352595 hasConceptScore W2011352595C68324877 @default.
- W2011352595 hasConceptScore W2011352595C71924100 @default.
- W2011352595 hasIssue "6" @default.
- W2011352595 hasLocation W20113525951 @default.
- W2011352595 hasLocation W20113525952 @default.
- W2011352595 hasLocation W20113525953 @default.
- W2011352595 hasOpenAccess W2011352595 @default.
- W2011352595 hasPrimaryLocation W20113525951 @default.
- W2011352595 hasRelatedWork W2033633711 @default.
- W2011352595 hasRelatedWork W2039065953 @default.
- W2011352595 hasRelatedWork W2099221997 @default.
- W2011352595 hasRelatedWork W2120026087 @default.
- W2011352595 hasRelatedWork W2171994438 @default.
- W2011352595 hasRelatedWork W2395305194 @default.
- W2011352595 hasRelatedWork W2411069689 @default.
- W2011352595 hasRelatedWork W2412223002 @default.
- W2011352595 hasRelatedWork W2438769438 @default.
- W2011352595 hasRelatedWork W2788022358 @default.
- W2011352595 hasVolume "18" @default.
- W2011352595 isParatext "false" @default.
- W2011352595 isRetracted "false" @default.
- W2011352595 magId "2011352595" @default.
- W2011352595 workType "article" @default.