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- W2011368541 abstract "he commentary by Drs Borst et aP presents a series of arguments that question several recent papers from independent groups, including our own, concerning possible roles for P-glycoprotein (P-gp) other than its established drug-pumping action in defense against xenotoxins.We concur that a greater effort is required to determine whether P-gp can generally protect cells from caspase-mediated cell death and/or mobilise dendritic cells (DC) to lymph nodes.We agree that rigorous assessment of these and other non-drug-efflux functions should be sought in vivo and broader study of the function of immune and haematopoietic systems of Mdrla/lb(-/-) gene knockout mice compared with wild-type mice would be a good starting point. Unfortunately, thus far, this has not happened. Hopefully, a larger picture of P-gp function in Mdrla/lb(-/-) gene knockout mice z can be gathered by collaborative efforts. However, even in the absence of such in vivo studies, we contend that the evidence supporting an additional role for P-gp and other ATP-Binding Cassette (ABC) transporters in apoptosis is" @default.
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- W2011368541 date "1998-01-01" @default.
- W2011368541 modified "2023-09-23" @default.
- W2011368541 title "The question begs — what is the role of P-glycoprotein in normal physiology?" @default.
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- W2011368541 doi "https://doi.org/10.1016/s1368-7646(98)80050-2" @default.
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